Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins

Although cholesterol is synthesized in the endoplasmic reticulum (ER), compared with other cellular membranes, ER membrane has low cholesterol (3-6%). Most of the molecular machinery that regulates cellular cholesterol homeostasis also resides in the ER. Little is known about how cholesterol itself...

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Veröffentlicht in:	Molecular biology of the cell 2006-04, Vol.17 (4), p.1593-1605
Hauptverfasser:	Ridsdale, Andrew, Denis, Maxime, Gougeon, Pierre-Yves, Ngsee, Johnny K, Presley, John F, Zha, Xiaohui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals CHO Cells Cholesterol - deficiency Cricetinae Cricetulus Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Fluorescence Recovery After Photobleaching Golgi Apparatus - metabolism Golgi Apparatus - ultrastructure Hydroxymethylglutaryl CoA Reductases - drug effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Membrane Glycoproteins - metabolism Membrane Proteins - metabolism Mevalonic Acid - pharmacology Protein Transport Secretory Vesicles - drug effects Secretory Vesicles - metabolism Viral Envelope Proteins - metabolism
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