A new variant t(6;15;17)(q25;q22;q21) in acute promyelocytic leukemia: fluorescence in situ hybridization confirmation

Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARα) at 17q21. The 2 chimeric genes PML/RARα and RARα/PML are thought to play a role in leukemogenesis....

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Veröffentlicht in:	Cancer genetics and cytogenetics 2005-05, Vol.159 (1), p.69-73
Hauptverfasser:	Eclache, Virginie, Viguie, Franck, Frocrain, Claudie, Cassinat, Bruno, Chomienne, Christine, Cymbalista, Florence, Fenaux, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome Banding Chromosomes, Human, Pair 15 - genetics Chromosomes, Human, Pair 17 - genetics Chromosomes, Human, Pair 6 - genetics Female Humans In Situ Hybridization, Fluorescence Leukemia, Promyelocytic, Acute - genetics Middle Aged Neoplasm Proteins - genetics Oncogene Proteins, Fusion - genetics Translocation, Genetic
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