The transcription factor c-jun is activated in retinal ganglion cells in experimental rat glaucoma

This study investigates the role of the MAP kinase pathway including c-jun, ATF-2 and JNK in glaucomatous eyes of rats and in optic nerve transection. Glaucoma was induced in one eye of 51 adult Wistar rats by laser treatment to the trabecular meshwork. Eighteen further rats underwent unilateral opt...

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Veröffentlicht in:	Experimental eye research 2005-05, Vol.80 (5), p.663-670
Hauptverfasser:	Levkovitch-Verbin, Hana, Quigley, Harry A., Martin, Keith R.G., Harizman, Noga, Valenta, Danielle F., Pease, Mary Ellen, Melamed, Shlomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 2 Animals Axotomy Blotting, Western - methods c-jun Cyclic AMP Response Element-Binding Protein - analysis Cyclic AMP Response Element-Binding Protein - metabolism glaucoma Glaucoma - metabolism Immunohistochemistry - methods JNK JNK Mitogen-Activated Protein Kinases - analysis JNK Mitogen-Activated Protein Kinases - metabolism Lasers MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases - analysis Mitogen-Activated Protein Kinase Kinases - metabolism Models, Animal Optic Nerve - pathology Optic Nerve Injuries - metabolism Optic Nerve Injuries - pathology optic nerve transection Phosphorylation Proto-Oncogene Proteins c-jun - analysis Proto-Oncogene Proteins c-jun - metabolism Rats Rats, Wistar retinal ganglion cells Retinal Ganglion Cells - chemistry Retinal Ganglion Cells - metabolism Trabeculectomy Transcription Factors - analysis Transcription Factors - metabolism
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