Age-related alteration of vitamin D metabolism in response to low-phosphate diet in rats

The responses of renal vitamin D metabolism to its major stimuli alter with age. Previous studies showed that the increase in circulating 1,25-dihydroxyvitamin D (1,25(OH)2D3) as well as renal 25-hydroxyvitamin D3 1-α hydroxylase (1-OHase) activity in response to dietary Ca or P restriction reduced...

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Veröffentlicht in:	British journal of nutrition 2005-03, Vol.93 (3), p.299-307
Hauptverfasser:	Chau, Tsui-Shan, Lai, Wan-Ping, Cheung, Pik-Yuen, Favus, Murray J., Wong, Man-Sau
Format:	Artikel
Sprache:	eng
Schlagworte:	1-alpha hydroxylase 24 hydroxylase 25-hydroxycholecalciferol 25-Hydroxyvitamin D3 1-α hydroxylase 25-Hydroxyvitamin D3 24 hydroxylase adult animals Adult rats Age Age Factors Aging - genetics Aging - metabolism animal models Animals Biological and medical sciences Biosynthesis Calcium - blood cholecalciferol Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Diet Down-Regulation enzyme activity Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Growth hormones Hypotheses Insulin-like growth factors Kidney - metabolism Low-phosphate diet Male messenger RNA Metabolism Metabolites Nutrition research nutrition-genotype interaction phosphates Phosphates - administration & dosage Phosphates - blood Rats Rats, Sprague-Dawley Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism RNA, Messenger - genetics senescence Steroid Hydroxylases - genetics Steroid Hydroxylases - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - metabolism Vitamin D receptor vitamin D receptors vitamin D-binding protein Vitamin D3 24-Hydroxylase vitamin deficiencies vitamin metabolism Weight Gain young animals
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