Hyperforin plasma level as a marker of treatment adherence in the national institutes of health hypericum depression trial

A previously reported clinical trial of Hypericum perforatum (St John's wort) in depression did not demonstrate efficacy. We assessed treatment adherence by measuring plasma hyperforin and evaluated the possible impact of adherence on study results. Outpatients with major depression (N = 340) w...

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Veröffentlicht in:	Journal of clinical psychopharmacology 2005-06, Vol.25 (3), p.243-249
Hauptverfasser:	VITIELLO, Benedetto, SHADER, Richard I, PARKER, Corette B, RITZ, Louise, HARLAN, William, GREENBLATT, David J, GADDE, Kishore M, KRISHNAN, K. Ranga R, DAVIDSON, Jonathan R. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Biomarkers - blood Bridged Bicyclo Compounds - blood Chi-Square Distribution Depressive Disorder, Major - blood Depressive Disorder, Major - drug therapy Double-Blind Method Female General pharmacology Humans Hypericum - metabolism Male Medical sciences Middle Aged National Institutes of Health (U.S.) Neuropharmacology Patient Compliance - statistics & numerical data Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phloroglucinol - analogs & derivatives Phloroglucinol - blood Statistics, Nonparametric Terpenes - blood United States
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