Potential use of biochemical markers of bone turnover for assessing the effect of calcium supplementation and predicting fracture risk
Biochemical markers of bone remodeling have been extensively used (independent of bone mass measurements) to document the efficacy of various anticatabolic and anabolic bone-modifying medications in reducing fracture risk. Nonetheless, their usefulness in determining the effectiveness of osteoporosi...
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| Veröffentlicht in: | Clinical therapeutics 2005-03, Vol.27 (3), p.299-308 |
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| creator | Weisman, Steven M. Matkovic, Velimir |
| description | Biochemical markers of bone remodeling have been extensively used (independent of bone mass measurements) to document the efficacy of various anticatabolic and anabolic bone-modifying medications in reducing fracture risk. Nonetheless, their usefulness in determining the effectiveness of osteoporosis prevention and treatment, particularly calcium supplementation, has not been well established.
This article reviews the use of biochemical markers of bone remodeling as a measure of the effect of calcium supplementation and the implications for prediction of fracture risk.
A generalized search of MEDLINE from 1966 through April 2004 using the terms
osteoporosis,
fracture risk, and the specific bone biomarkers of interest was conducted to identify articles relating to these biomarkers and their relationship to prediction of fracture risk. A second MEDLINE search for the same period used the terms
calcium, biological markers, and
fracture risk to identify studies of calcium supplementation and bone biomarkers. In both cases, the reference lists of identified review articles were searched for additional publications.
Several biochemical markers of bone remodeling have been shown to be positively correlated with bone mineral density and fracture risk. Furthermore, calcium supplementation has been shown to have a significant correlation with levels of a number of these biomarkers (
P < 0.05): the markers of bone formation procollagen type I carboxy and amino terminal peptides and serum bone-specific alkaline phosphatase, and the markers of bone resorption urinary hydroxyproline, urinary pyridinoline, urinary deoxypyridinoline, urinary amino terminal crosslinked telopeptide, and urinary and serum carboxy terminal crosslinked telopeptide.
Calcium supplementation has a significant effect on a number of biomarkers of bone remodeling, an effect that is, in turn, correlated with decreased fracture risk. Most studies of the efficacy of calcium supplementation in reducing bone remodeling and influencing bone mineral density and fracture risk have involved calcium carbonate, although a few studies have found that other calcium salts may produce similar results. |
| doi_str_mv | 10.1016/j.dinthera.2005.03.003 |
| format | Article |
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This article reviews the use of biochemical markers of bone remodeling as a measure of the effect of calcium supplementation and the implications for prediction of fracture risk.
A generalized search of MEDLINE from 1966 through April 2004 using the terms
osteoporosis,
fracture risk, and the specific bone biomarkers of interest was conducted to identify articles relating to these biomarkers and their relationship to prediction of fracture risk. A second MEDLINE search for the same period used the terms
calcium, biological markers, and
fracture risk to identify studies of calcium supplementation and bone biomarkers. In both cases, the reference lists of identified review articles were searched for additional publications.
Several biochemical markers of bone remodeling have been shown to be positively correlated with bone mineral density and fracture risk. Furthermore, calcium supplementation has been shown to have a significant correlation with levels of a number of these biomarkers (
P < 0.05): the markers of bone formation procollagen type I carboxy and amino terminal peptides and serum bone-specific alkaline phosphatase, and the markers of bone resorption urinary hydroxyproline, urinary pyridinoline, urinary deoxypyridinoline, urinary amino terminal crosslinked telopeptide, and urinary and serum carboxy terminal crosslinked telopeptide.
Calcium supplementation has a significant effect on a number of biomarkers of bone remodeling, an effect that is, in turn, correlated with decreased fracture risk. Most studies of the efficacy of calcium supplementation in reducing bone remodeling and influencing bone mineral density and fracture risk have involved calcium carbonate, although a few studies have found that other calcium salts may produce similar results.</description><identifier>ISSN: 0149-2918</identifier><identifier>EISSN: 1879-114X</identifier><identifier>DOI: 10.1016/j.dinthera.2005.03.003</identifier><identifier>PMID: 15878383</identifier><language>eng</language><publisher>Belle Mead, NJ: EM Inc USA</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - analysis ; bone biomarkers ; Bone density ; Bone Remodeling - physiology ; Calcium - therapeutic use ; calcium supplements ; Dietary Supplements ; Female ; fracture risk ; Fractures ; Fractures, Bone - etiology ; Fractures, Bone - prevention & control ; Health care ; Hip joint ; Humans ; Male ; Medical sciences ; Metabolism ; Middle Aged ; Older people ; Osteoporosis ; Osteoporosis - complications ; Pharmacology. Drug treatments ; review ; Risk ; Vitamin D ; Womens health ; Young adults</subject><ispartof>Clinical therapeutics, 2005-03, Vol.27 (3), p.299-308</ispartof><rights>2005 Excerpta Medica, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-804d8f23e5ed7f313b11a144fd4d0af63c06fc2eb1428c67f6827ab48a600c573</citedby><cites>FETCH-LOGICAL-c354t-804d8f23e5ed7f313b11a144fd4d0af63c06fc2eb1428c67f6827ab48a600c573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0149291805000469$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16863791$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15878383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weisman, Steven M.</creatorcontrib><creatorcontrib>Matkovic, Velimir</creatorcontrib><title>Potential use of biochemical markers of bone turnover for assessing the effect of calcium supplementation and predicting fracture risk</title><title>Clinical therapeutics</title><addtitle>Clin Ther</addtitle><description>Biochemical markers of bone remodeling have been extensively used (independent of bone mass measurements) to document the efficacy of various anticatabolic and anabolic bone-modifying medications in reducing fracture risk. Nonetheless, their usefulness in determining the effectiveness of osteoporosis prevention and treatment, particularly calcium supplementation, has not been well established.
This article reviews the use of biochemical markers of bone remodeling as a measure of the effect of calcium supplementation and the implications for prediction of fracture risk.
A generalized search of MEDLINE from 1966 through April 2004 using the terms
osteoporosis,
fracture risk, and the specific bone biomarkers of interest was conducted to identify articles relating to these biomarkers and their relationship to prediction of fracture risk. A second MEDLINE search for the same period used the terms
calcium, biological markers, and
fracture risk to identify studies of calcium supplementation and bone biomarkers. In both cases, the reference lists of identified review articles were searched for additional publications.
Several biochemical markers of bone remodeling have been shown to be positively correlated with bone mineral density and fracture risk. Furthermore, calcium supplementation has been shown to have a significant correlation with levels of a number of these biomarkers (
P < 0.05): the markers of bone formation procollagen type I carboxy and amino terminal peptides and serum bone-specific alkaline phosphatase, and the markers of bone resorption urinary hydroxyproline, urinary pyridinoline, urinary deoxypyridinoline, urinary amino terminal crosslinked telopeptide, and urinary and serum carboxy terminal crosslinked telopeptide.
Calcium supplementation has a significant effect on a number of biomarkers of bone remodeling, an effect that is, in turn, correlated with decreased fracture risk. Most studies of the efficacy of calcium supplementation in reducing bone remodeling and influencing bone mineral density and fracture risk have involved calcium carbonate, although a few studies have found that other calcium salts may produce similar results.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>bone biomarkers</subject><subject>Bone density</subject><subject>Bone Remodeling - physiology</subject><subject>Calcium - therapeutic use</subject><subject>calcium supplements</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>fracture risk</subject><subject>Fractures</subject><subject>Fractures, Bone - etiology</subject><subject>Fractures, Bone - prevention & control</subject><subject>Health care</subject><subject>Hip joint</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Pharmacology. Drug treatments</subject><subject>review</subject><subject>Risk</subject><subject>Vitamin D</subject><subject>Womens health</subject><subject>Young adults</subject><issn>0149-2918</issn><issn>1879-114X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc9qFTEYxYMo9rb6CiUgupsx_yaT2SlFrVCwiwruQibzxeZ2JhmTmYIv0Oc2471ScNNV4ON3DifnIHROSU0Jle_39eDDcgvJ1IyQpia8JoQ_Qzuq2q6iVPx4jnaEiq5iHVUn6DTnPSlE17CX6IQ2qlVc8R16uI4LhMWbEa8ZcHS499HewuRtOU0m3UHKf88xAF7WFOI9JOxiwiZnyNmHn7jkwOAc2GUji9D6dcJ5necRpuJuFh8DNmHAc4LB22UTuWRs8QOcfL57hV44M2Z4fXzP0PfPn24uLqurb1--Xny8qixvxFIpIgblGIcGhtZxyntKDRXCDWIgxkluiXSWQU8FU1a2TirWml4oIwmxTcvP0LuD75zirxXyoiefLYyjCRDXrGWrCGNyA9_8B-5j-XzJpinhrGOiZRslD5RNMecETs_Jl9J-F0hvO-m9_reT3nbShOuyQhGeH-3XfoLhUXYcpgBvj4DJpdBSVrA-P3JSSd52tHAfDhyU1u49JJ2th2BLzansoYfon8ryB9jJtsk</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Weisman, Steven M.</creator><creator>Matkovic, Velimir</creator><general>EM Inc USA</general><general>Excerpta Medica</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Potential use of biochemical markers of bone turnover for assessing the effect of calcium supplementation and predicting fracture risk</title><author>Weisman, Steven M. ; Matkovic, Velimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-804d8f23e5ed7f313b11a144fd4d0af63c06fc2eb1428c67f6827ab48a600c573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>bone biomarkers</topic><topic>Bone density</topic><topic>Bone Remodeling - physiology</topic><topic>Calcium - therapeutic use</topic><topic>calcium supplements</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>fracture risk</topic><topic>Fractures</topic><topic>Fractures, Bone - etiology</topic><topic>Fractures, Bone - prevention & control</topic><topic>Health care</topic><topic>Hip joint</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Pharmacology. 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Nonetheless, their usefulness in determining the effectiveness of osteoporosis prevention and treatment, particularly calcium supplementation, has not been well established.
This article reviews the use of biochemical markers of bone remodeling as a measure of the effect of calcium supplementation and the implications for prediction of fracture risk.
A generalized search of MEDLINE from 1966 through April 2004 using the terms
osteoporosis,
fracture risk, and the specific bone biomarkers of interest was conducted to identify articles relating to these biomarkers and their relationship to prediction of fracture risk. A second MEDLINE search for the same period used the terms
calcium, biological markers, and
fracture risk to identify studies of calcium supplementation and bone biomarkers. In both cases, the reference lists of identified review articles were searched for additional publications.
Several biochemical markers of bone remodeling have been shown to be positively correlated with bone mineral density and fracture risk. Furthermore, calcium supplementation has been shown to have a significant correlation with levels of a number of these biomarkers (
P < 0.05): the markers of bone formation procollagen type I carboxy and amino terminal peptides and serum bone-specific alkaline phosphatase, and the markers of bone resorption urinary hydroxyproline, urinary pyridinoline, urinary deoxypyridinoline, urinary amino terminal crosslinked telopeptide, and urinary and serum carboxy terminal crosslinked telopeptide.
Calcium supplementation has a significant effect on a number of biomarkers of bone remodeling, an effect that is, in turn, correlated with decreased fracture risk. Most studies of the efficacy of calcium supplementation in reducing bone remodeling and influencing bone mineral density and fracture risk have involved calcium carbonate, although a few studies have found that other calcium salts may produce similar results.</abstract><cop>Belle Mead, NJ</cop><pub>EM Inc USA</pub><pmid>15878383</pmid><doi>10.1016/j.dinthera.2005.03.003</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-2918 |
| ispartof | Clinical therapeutics, 2005-03, Vol.27 (3), p.299-308 |
| issn | 0149-2918 1879-114X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers - analysis bone biomarkers Bone density Bone Remodeling - physiology Calcium - therapeutic use calcium supplements Dietary Supplements Female fracture risk Fractures Fractures, Bone - etiology Fractures, Bone - prevention & control Health care Hip joint Humans Male Medical sciences Metabolism Middle Aged Older people Osteoporosis Osteoporosis - complications Pharmacology. Drug treatments review Risk Vitamin D Womens health Young adults |
| title | Potential use of biochemical markers of bone turnover for assessing the effect of calcium supplementation and predicting fracture risk |
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