Involvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermia
Hypoxia causes a regulated decrease in body temperature (Tb). There is circumstantial evidence that the neurotransmitter serotonin (5-HT) in the anteroventral preoptic region (AVPO) mediates this response. However, which 5-HT receptor(s) is (are) involved in this response has not been assessed. Thus...
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| description | Hypoxia causes a regulated decrease in body temperature (Tb). There is circumstantial evidence that the neurotransmitter serotonin (5-HT) in the anteroventral preoptic region (AVPO) mediates this response. However, which 5-HT receptor(s) is (are) involved in this response has not been assessed. Thus, we investigated the participation of the 5-HT receptors (5-HT
1, 5-HT
2, and 5-HT
7) in the AVPO in hypoxic hypothermia. To this end, Tb of conscious Wistar rats was monitored by biotelemetry before and after intra-AVPO microinjection of methysergide (a 5-HT
1 and 5-HT
2 receptor antagonist, 0.2 and 2 μg/100 nL), WAY-100635 (a 5-HT
1A receptor antagonist, 0.3 and 3 μg/100 nL), and SB-269970 (a 5-HT
7 receptor antagonist, 0.4 and 4 μ/100 nL), followed by 60 min of hypoxia exposure (7% O
2). During the experiments, the mean chamber temperature was 24.6 ± 0.7 °C (mean ± SE) and the mean room temperature was 23.5 ± 0.8 °C (mean ± SE). Intra-AVPO microinjection of vehicle or 5-HT antagonists did not change Tb during normoxic conditions. Exposure of rats to 7% of inspired oxygen evoked typical hypoxia-induced hypothermia after vehicle microinjection, which was not affected by both doses of methysergide. However, WAY-100635 and SB-269970 treatment attenuated the drop in Tb in response to hypoxia. The effect was more pronounced with the 5-HT
7 antagonist since both doses (0.4 and 4 μg/0.1μL) were capable of attenuating the hypothermic response. As to the 5-HT
1A antagonist, the attenuation of hypoxia-induced hypothermia was only observed at the higher dose. Therefore, the present results are consistent with the notion that 5-HT acts on both 5-HT
1A and 5-HT
7 receptors in the AVPO to induce hypothermia, during hypoxia. |
| doi_str_mv | 10.1016/j.brainres.2005.02.069 |
| format | Article |
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1, 5-HT
2, and 5-HT
7) in the AVPO in hypoxic hypothermia. To this end, Tb of conscious Wistar rats was monitored by biotelemetry before and after intra-AVPO microinjection of methysergide (a 5-HT
1 and 5-HT
2 receptor antagonist, 0.2 and 2 μg/100 nL), WAY-100635 (a 5-HT
1A receptor antagonist, 0.3 and 3 μg/100 nL), and SB-269970 (a 5-HT
7 receptor antagonist, 0.4 and 4 μ/100 nL), followed by 60 min of hypoxia exposure (7% O
2). During the experiments, the mean chamber temperature was 24.6 ± 0.7 °C (mean ± SE) and the mean room temperature was 23.5 ± 0.8 °C (mean ± SE). Intra-AVPO microinjection of vehicle or 5-HT antagonists did not change Tb during normoxic conditions. Exposure of rats to 7% of inspired oxygen evoked typical hypoxia-induced hypothermia after vehicle microinjection, which was not affected by both doses of methysergide. However, WAY-100635 and SB-269970 treatment attenuated the drop in Tb in response to hypoxia. The effect was more pronounced with the 5-HT
7 antagonist since both doses (0.4 and 4 μg/0.1μL) were capable of attenuating the hypothermic response. As to the 5-HT
1A antagonist, the attenuation of hypoxia-induced hypothermia was only observed at the higher dose. Therefore, the present results are consistent with the notion that 5-HT acts on both 5-HT
1A and 5-HT
7 receptors in the AVPO to induce hypothermia, during hypoxia.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2005.02.069</identifier><identifier>PMID: 15862785</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Body Temperature - drug effects ; Body Temperature - physiology ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Hypothermia ; Hypothermia - etiology ; Hypothermia - metabolism ; Hypoxia ; Hypoxia - complications ; Male ; Microinjections - methods ; Multivariate Analysis ; Preoptic area ; Preoptic Area - metabolism ; Rats ; Rats, Wistar ; Receptors, Serotonin - classification ; Receptors, Serotonin - physiology ; Serotonin ; Serotonin Antagonists - pharmacology ; Thermoregulation ; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Brain research, 2005-05, Vol.1044 (1), p.16-24</ispartof><rights>2005 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-68826527f33150a12f45beb36020ef97a0b9407eae9094f4257559f1019c07fc3</citedby><cites>FETCH-LOGICAL-c524t-68826527f33150a12f45beb36020ef97a0b9407eae9094f4257559f1019c07fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899305003628$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16756532$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15862785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gargaglioni, Luciane H.</creatorcontrib><creatorcontrib>Steiner, Alexandre A.</creatorcontrib><creatorcontrib>Branco, Luiz G.S.</creatorcontrib><title>Involvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermia</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Hypoxia causes a regulated decrease in body temperature (Tb). There is circumstantial evidence that the neurotransmitter serotonin (5-HT) in the anteroventral preoptic region (AVPO) mediates this response. However, which 5-HT receptor(s) is (are) involved in this response has not been assessed. Thus, we investigated the participation of the 5-HT receptors (5-HT
1, 5-HT
2, and 5-HT
7) in the AVPO in hypoxic hypothermia. To this end, Tb of conscious Wistar rats was monitored by biotelemetry before and after intra-AVPO microinjection of methysergide (a 5-HT
1 and 5-HT
2 receptor antagonist, 0.2 and 2 μg/100 nL), WAY-100635 (a 5-HT
1A receptor antagonist, 0.3 and 3 μg/100 nL), and SB-269970 (a 5-HT
7 receptor antagonist, 0.4 and 4 μ/100 nL), followed by 60 min of hypoxia exposure (7% O
2). During the experiments, the mean chamber temperature was 24.6 ± 0.7 °C (mean ± SE) and the mean room temperature was 23.5 ± 0.8 °C (mean ± SE). Intra-AVPO microinjection of vehicle or 5-HT antagonists did not change Tb during normoxic conditions. Exposure of rats to 7% of inspired oxygen evoked typical hypoxia-induced hypothermia after vehicle microinjection, which was not affected by both doses of methysergide. However, WAY-100635 and SB-269970 treatment attenuated the drop in Tb in response to hypoxia. The effect was more pronounced with the 5-HT
7 antagonist since both doses (0.4 and 4 μg/0.1μL) were capable of attenuating the hypothermic response. As to the 5-HT
1A antagonist, the attenuation of hypoxia-induced hypothermia was only observed at the higher dose. Therefore, the present results are consistent with the notion that 5-HT acts on both 5-HT
1A and 5-HT
7 receptors in the AVPO to induce hypothermia, during hypoxia.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Body Temperature - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothermia</subject><subject>Hypothermia - etiology</subject><subject>Hypothermia - metabolism</subject><subject>Hypoxia</subject><subject>Hypoxia - complications</subject><subject>Male</subject><subject>Microinjections - methods</subject><subject>Multivariate Analysis</subject><subject>Preoptic area</subject><subject>Preoptic Area - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Serotonin - classification</subject><subject>Receptors, Serotonin - physiology</subject><subject>Serotonin</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Thermoregulation</subject><subject>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1vFCEUhonR2LX6F5q50bsZDzDAcKdp_GjSxBu9Jgx7aFlnYITZjf330u6aXm5CQk7yvHDyPoRcUegoUPlx143ZhpixdAxAdMA6kPoF2dBBsVayHl6SDQDIdtCaX5A3pezqyLmG1-SCikEyNYgN-X0TD2k64IxxbZJvCua0phgi5rvgmowOlzXl0oTYrPfY2LhW4lDpbKdmyZiW9Ym7Cyk29dw_LOlvsG2I273D7dNcg3kO9i155e1U8N3pviS_vn75ef29vf3x7eb6823rBOvXVg4Dk4IpzzkVYCnzvRhx5BIYoNfKwqh7UGhRg-59z4QSQvtai3agvOOX5MPx3SWnP3ssq5lDcThNNmLaFyPVUCuk-izIQFGhhvMgVVxI3csKyiPociolozdLDrPND4aCeRRndua_OPMozgAzVVwNXp1-2I8zbp9jJ1MVeH8CbHF28tlGF8ozJ5WQgrPKfTpyWBs-BMymuICxqghV5mq2KZzb5R8iLbuF</recordid><startdate>20050517</startdate><enddate>20050517</enddate><creator>Gargaglioni, Luciane H.</creator><creator>Steiner, Alexandre A.</creator><creator>Branco, Luiz G.S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050517</creationdate><title>Involvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermia</title><author>Gargaglioni, Luciane H. ; Steiner, Alexandre A. ; Branco, Luiz G.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-68826527f33150a12f45beb36020ef97a0b9407eae9094f4257559f1019c07fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature - drug effects</topic><topic>Body Temperature - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothermia</topic><topic>Hypothermia - etiology</topic><topic>Hypothermia - metabolism</topic><topic>Hypoxia</topic><topic>Hypoxia - complications</topic><topic>Male</topic><topic>Microinjections - methods</topic><topic>Multivariate Analysis</topic><topic>Preoptic area</topic><topic>Preoptic Area - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Serotonin - classification</topic><topic>Receptors, Serotonin - physiology</topic><topic>Serotonin</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Thermoregulation</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gargaglioni, Luciane H.</creatorcontrib><creatorcontrib>Steiner, Alexandre A.</creatorcontrib><creatorcontrib>Branco, Luiz G.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gargaglioni, Luciane H.</au><au>Steiner, Alexandre A.</au><au>Branco, Luiz G.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermia</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2005-05-17</date><risdate>2005</risdate><volume>1044</volume><issue>1</issue><spage>16</spage><epage>24</epage><pages>16-24</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Hypoxia causes a regulated decrease in body temperature (Tb). There is circumstantial evidence that the neurotransmitter serotonin (5-HT) in the anteroventral preoptic region (AVPO) mediates this response. However, which 5-HT receptor(s) is (are) involved in this response has not been assessed. Thus, we investigated the participation of the 5-HT receptors (5-HT
1, 5-HT
2, and 5-HT
7) in the AVPO in hypoxic hypothermia. To this end, Tb of conscious Wistar rats was monitored by biotelemetry before and after intra-AVPO microinjection of methysergide (a 5-HT
1 and 5-HT
2 receptor antagonist, 0.2 and 2 μg/100 nL), WAY-100635 (a 5-HT
1A receptor antagonist, 0.3 and 3 μg/100 nL), and SB-269970 (a 5-HT
7 receptor antagonist, 0.4 and 4 μ/100 nL), followed by 60 min of hypoxia exposure (7% O
2). During the experiments, the mean chamber temperature was 24.6 ± 0.7 °C (mean ± SE) and the mean room temperature was 23.5 ± 0.8 °C (mean ± SE). Intra-AVPO microinjection of vehicle or 5-HT antagonists did not change Tb during normoxic conditions. Exposure of rats to 7% of inspired oxygen evoked typical hypoxia-induced hypothermia after vehicle microinjection, which was not affected by both doses of methysergide. However, WAY-100635 and SB-269970 treatment attenuated the drop in Tb in response to hypoxia. The effect was more pronounced with the 5-HT
7 antagonist since both doses (0.4 and 4 μg/0.1μL) were capable of attenuating the hypothermic response. As to the 5-HT
1A antagonist, the attenuation of hypoxia-induced hypothermia was only observed at the higher dose. Therefore, the present results are consistent with the notion that 5-HT acts on both 5-HT
1A and 5-HT
7 receptors in the AVPO to induce hypothermia, during hypoxia.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>15862785</pmid><doi>10.1016/j.brainres.2005.02.069</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Body Temperature - drug effects Body Temperature - physiology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Hypothermia Hypothermia - etiology Hypothermia - metabolism Hypoxia Hypoxia - complications Male Microinjections - methods Multivariate Analysis Preoptic area Preoptic Area - metabolism Rats Rats, Wistar Receptors, Serotonin - classification Receptors, Serotonin - physiology Serotonin Serotonin Antagonists - pharmacology Thermoregulation Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Involvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermia |
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