Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents

The major heat shock protein Hsp72 is expressed at high levels in various types of cancer. Here we attempt to clarify the role of Hsp72 in prostate cancer cells by studying the effects of specific downregulation of this protein using siRNA and antisense RNA approaches. Contrary to previous reports,...

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Veröffentlicht in:	Oncogene 2005-05, Vol.24 (20), p.3328-3338
Hauptverfasser:	GABAI, Vladimir L, BUDAGOVA, Karine R, SHERMAN, Michael Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Antineoplastic Agents - pharmacology Antisense RNA Antitumor agents Apoptosis Cancer Cancer therapies Cell death Cell Line, Tumor Cell Survival Coloring Agents - pharmacology Down-Regulation Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Genetic Vectors Heat shock proteins Heat-Shock Proteins - physiology HSP72 Heat-Shock Proteins Hsp72 protein Hsp90 protein Humans Hyperthermia Immunoblotting Male Medical prognosis NF-kappa B - metabolism NF-κB protein Oxidative Stress Paclitaxel Prostate Prostate cancer Prostate carcinoma Prostatic Neoplasms - metabolism Proteasomes Radiation Retroviridae - genetics RNA, Small Interfering - metabolism siRNA Tetrazolium Salts - pharmacology Thiazoles - pharmacology Time Factors Tumor cell lines Tumor necrosis factor-TNF Tumors
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