Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light

Exposure to sources of UV radiation, such as sunlight, induces a number of cellular alterations that are highly dependent on its ability to affect gene expression. Among them, the rapid activation of genes coding for two subfamilies of proto-oncoproteins, Fos and Jun, which constitute the AP-1 trans...

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Veröffentlicht in:	The Journal of biological chemistry 2005-05, Vol.280 (19), p.18842-18852
Hauptverfasser:	Tanos, Tamara, Marinissen, Maria Julia, Leskow, Federico Coluccio, Hochbaum, Daniel, Martinetto, Horacio, Gutkind, J Silvio, Coso, Omar A
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Apoptosis Binding Sites Blotting, Western Cell Cycle Cell Line Cell Nucleus - metabolism DNA - chemistry DNA Damage Electrophoresis, Polyacrylamide Gel Enzyme Inhibitors - pharmacology Extracellular Matrix - metabolism Fluorescent Antibody Technique, Indirect Genes, Reporter Glutathione Transferase - metabolism HeLa Cells Humans Luciferases - metabolism Mice Microscopy, Fluorescence Models, Biological NIH 3T3 Cells p38 Mitogen-Activated Protein Kinases - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Protein Isoforms Proto-Oncogene Proteins c-fos - chemistry Recombinant Fusion Proteins - chemistry Subcellular Fractions Time Factors Transcription Factor AP-1 - chemistry Transcription, Genetic Transcriptional Activation Transfection Two-Hybrid System Techniques Ultraviolet Rays
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