Intramolecular Hydroamination of Unactived Olefins with Ti(NMe2)4 as a Precatalyst
Commercially available Ti(NMe2)4 has been used effectively as a precatalyst in a facile protocol for the intramolecular hydroamination of aminoalkenes to yield pyrrolidine and piperidine heterocyclic products with isolated yields up to 92%. Geminally substituted substrates display the highest reacti...
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Veröffentlicht in: | Organic letters 2005-05, Vol.7 (10), p.1959-1962 |
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container_end_page | 1962 |
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container_issue | 10 |
container_start_page | 1959 |
container_title | Organic letters |
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creator | Bexrud, Jason A Beard, J. David Leitch, David C Schafer, Laurel L |
description | Commercially available Ti(NMe2)4 has been used effectively as a precatalyst in a facile protocol for the intramolecular hydroamination of aminoalkenes to yield pyrrolidine and piperidine heterocyclic products with isolated yields up to 92%. Geminally substituted substrates display the highest reactivity. This precatalyst is also effective for the hydroamination of activated internal alkenes, providing access to more complex heterocyclic target molecules. |
doi_str_mv | 10.1021/ol0503992 |
format | Article |
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title | Intramolecular Hydroamination of Unactived Olefins with Ti(NMe2)4 as a Precatalyst |
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