Role of the carboxyl terminal stop transfer sequence of UGT1A6 membrane protein in ER targeting and translocation of upstream lumenal domain

We investigated the role of the stop transfer sequence of human UGT1A6 in ER assembly and enzyme activity. We found that this sequence was able to address and translocate the upstream lumenal domain into microsomal membranes in vitro co- and posttranslationally. The signal activity of this sequence...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 2006-04, Vol.580 (8), p.1953-1958
Hauptverfasser:	Ouzzine, M., Barré, L., Netter, P., Magdalou, J., Fournel-Gigleux, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Amino Acid Sequence cytosolic tail endoplasmic reticulum Endoplasmic Reticulum - enzymology Endoplasmic Reticulum - metabolism ER targeting and translocation Glucuronosyltransferase - chemistry Glucuronosyltransferase - metabolism HeLa Cells Humans Membrane protein Membrane Proteins - chemistry Membrane Proteins - metabolism Molecular Sequence Data Pichia - metabolism Protein Processing, Post-Translational Protein Sorting Signals - physiology Protein Structure, Tertiary Protein Transport Sequence Deletion - genetics Stop transfer sequence TMD transmembrane domain UDP-glucuronosyltransferase UGT UGT1A6
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!