Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry

1 Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, Lexington, MA 02421, USA 2 Cubist Pharmaceuticals, Slough, 545 Ipswich Road, Slough SL1 4EQ, UK Correspondence Vivian Miao vmiao{at}cubist.com Daptomycin is a 13 amino acid, cyclic lipopeptide produced by a non-ribosomal peptide synthetase (NRPS) mec...

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Veröffentlicht in:	Microbiology (Society for General Microbiology) 2005-05, Vol.151 (5), p.1507-1523
Hauptverfasser:	Miao, Vivian, Coeffet-LeGal, Marie-Francoise, Brian, Paul, Brost, Renee, Penn, Julia, Whiting, Andrew, Martin, Steven, Ford, Robert, Parr, Ian, Bouchard, Mario, Silva, Christopher J, Wrigley, Stephen K, Baltz, Richard H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Base Sequence Biological and medical sciences Cloning, Molecular Conserved Sequence Daptomycin - biosynthesis Fundamental and applied biological sciences. Psychology Genetics Microbiology Molecular Sequence Data Multigene Family Open Reading Frames Peptide Synthases - chemistry Peptide Synthases - genetics Peptide Synthases - metabolism Peptides, Cyclic - biosynthesis Peptides, Cyclic - chemistry Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism Sequence Analysis, DNA Stereoisomerism Streptomyces - enzymology Streptomyces - genetics Streptomyces - metabolism Streptomyces lividans - enzymology Streptomyces lividans - genetics Streptomyces lividans - metabolism
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