Erythropoietin activates caspase-3 and downregulates CAD during erythroid differentiation in TF-1 cells – A protection mechanism against DNA fragmentation

The involvement of caspase-3 and its failure in the induction of DNA fragmentation during erythropoiesis were investigated with TF-1 cells. During erythroid differentiation, caspase-3 activation and cleavage of caspase-3 substrates such as ICAD (inhibitor of caspase-activated DNase) were detected wi...

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Veröffentlicht in:	FEBS letters 2006-04, Vol.580 (8), p.1965-1970
Hauptverfasser:	Lui, Julian Chun-Kin, Kong, Siu-Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis Regulatory Proteins CAD Caspase 3 Caspase Inhibitors caspase-activated DNase Caspases - metabolism Cell Differentiation Cells, Cultured Deoxyribonucleases - genetics Deoxyribonucleases - metabolism DNA fragmentation DNA Fragmentation - drug effects Down-Regulation - genetics Enzyme Activation EPO Erythroid Cells - cytology Erythroid Cells - enzymology Erythroid differentiation Erythropoiesis - physiology erythropoietin Erythropoietin - pharmacology GADPH Gene Expression glyceraldehyde-3-phosphate dehydrogenase glycophorin A GM-CSF GPA granulocyte-macrophage colony stimulating factor hemoglobin Humans ICAD inhibitor of the caspase-activated DNase MAb monoclonal antibody PARP phosphatidylserine poly (ADP-ribose) polymerase Poly(ADP-ribose) Polymerases propidium iodide Proteins - genetics Proteins - metabolism Recombinant Proteins RNA, Messenger - genetics RNA, Messenger - metabolism staurosporine STS terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling TUNEL
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