A temperature-sensitive mutation in the WD repeat-containing protein Smu1 is related to maintenance of chromosome integrity

Temperature-sensitive CHO-K1 mutant cell line tsTM18 exhibits chromosomal instability and cell cycle arrest at S and G 2 phases with decreased DNA synthesis at the nonpermissive temperature, 39°C. To identify the causative mutation, we fused tsTM18 cells with normal human cells to generate hybrids c...

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Veröffentlicht in:	Experimental cell research 2005-05, Vol.306 (1), p.242-251
Hauptverfasser:	Sugaya, Kimihiko, Hongo, Etsuko, Tsuji, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals CDC2 Protein Kinase - metabolism Cell cycle arrest Cell Cycle Proteins - genetics Cell Fusion Cell Line Cell Nucleus - metabolism CHO Cells Chromosomal Instability - genetics Chromosomal Proteins, Non-Histone - genetics Chromosome Aberrations Chromosome instability Chromosomes, Human, Pair 9 - genetics Cloning, Molecular Cricetinae Cricetulus DNA - genetics DNA - isolation & purification DNA, Complementary - chemistry DNA, Complementary - genetics DNA, Single-Stranded - metabolism Genetic Complementation Test Humans Mitosis - genetics Molecular Sequence Data Mutation - genetics Point Mutation Sequence Analysis, DNA Sequence Homology, Amino Acid Single-stranded DNA Spindle Apparatus - genetics Spindle Apparatus - metabolism Temperature Temperature-sensitive mutation WD repeats
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