Alpha-synuclein mRNA expression in sporadic Parkinson's disease
The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.11...
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| Veröffentlicht in: | Movement disorders 2005-05, Vol.20 (5), p.620-623 |
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| creator | Tan, Eng-King Chandran, Van R. Fook-Chong, Stephanie Shen, Hui Yew, Kenneth Teoh, Mei-Lin Yuen, Yih Zhao, Yi |
| description | The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of α‐synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined. © 2005 Movement Disorder Society |
| doi_str_mv | 10.1002/mds.20391 |
| format | Article |
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By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. 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Cerebral palsy ; Humans ; Male ; Medical sciences ; Middle Aged ; mRNA ; Multivariate Analysis ; Mutation, Missense - genetics ; Nerve Tissue Proteins - genetics ; Nervous system (semeiology, syndromes) ; Neurology ; Parkinson Disease - genetics ; Parkinson's disease ; Polymerase Chain Reaction ; RNA, Messenger - genetics ; Synucleins</subject><ispartof>Movement disorders, 2005-05, Vol.20 (5), p.620-623</ispartof><rights>Copyright © 2005 Movement Disorder Society</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2005 Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4571-4e6ea3fadbdfbd5f044b2a437df61bd76ffb30730c9a2db5f9596204c90b9ba53</citedby><cites>FETCH-LOGICAL-c4571-4e6ea3fadbdfbd5f044b2a437df61bd76ffb30730c9a2db5f9596204c90b9ba53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.20391$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.20391$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16840956$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15719423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Eng-King</creatorcontrib><creatorcontrib>Chandran, Van R.</creatorcontrib><creatorcontrib>Fook-Chong, Stephanie</creatorcontrib><creatorcontrib>Shen, Hui</creatorcontrib><creatorcontrib>Yew, Kenneth</creatorcontrib><creatorcontrib>Teoh, Mei-Lin</creatorcontrib><creatorcontrib>Yuen, Yih</creatorcontrib><creatorcontrib>Zhao, Yi</creatorcontrib><title>Alpha-synuclein mRNA expression in sporadic Parkinson's disease</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of α‐synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined. © 2005 Movement Disorder Society</description><subject>alpha-Synuclein</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>DNA Primers - genetics</subject><subject>Female</subject><subject>gene dosage</subject><subject>Gene Expression - genetics</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mRNA</subject><subject>Multivariate Analysis</subject><subject>Mutation, Missense - genetics</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson's disease</subject><subject>Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>Synucleins</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UtPVDEYBuDGaGAEFv4BczZiXBxoT2-nKzKi3AJIUGPipuk1Vs7Nfkxk_j3FGWVFXDVpnu9707cIvSJ4j2Dc7Pce9hpMFXmGZoRTUrcNl8_RDLctrylp-SZ6CfATY0I4ERtok3BJFGvoDB3Mu-mHqWE5LFwX0lD115fzKtxNOQCkcajKFUxjNj656srkmzTAOLyFyicIBsI2ehFNB2FnfW6hr0cfvxye1Oefjk8P5-e1YyWrZkEEQ6Px1kfrecSM2cYwKn0UxHopYrQUS4qdMo23PCquRIOZU9gqazjdQrurvVMefy0C3Oo-gQtdZ4YwLkALKZVinP0XNqUDIQUp8N0KujwC5BD1lFNv8lITrB9q1aVW_afWYl-vly5sH_yjXPdYwJs1MOBMF7MZXIJHJ1qGFRfF7a_c79SF5dOJ-uLD57_R9WoiwW24-zdRfqK8mUquv10e64vvJ-rsveL6mt4Dy_udVg</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Tan, Eng-King</creator><creator>Chandran, Van R.</creator><creator>Fook-Chong, Stephanie</creator><creator>Shen, Hui</creator><creator>Yew, Kenneth</creator><creator>Teoh, Mei-Lin</creator><creator>Yuen, Yih</creator><creator>Zhao, Yi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200505</creationdate><title>Alpha-synuclein mRNA expression in sporadic Parkinson's disease</title><author>Tan, Eng-King ; Chandran, Van R. ; Fook-Chong, Stephanie ; Shen, Hui ; Yew, Kenneth ; Teoh, Mei-Lin ; Yuen, Yih ; Zhao, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4571-4e6ea3fadbdfbd5f044b2a437df61bd76ffb30730c9a2db5f9596204c90b9ba53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>alpha-Synuclein</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>DNA Primers - genetics</topic><topic>Female</topic><topic>gene dosage</topic><topic>Gene Expression - genetics</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. 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| subjects | alpha-Synuclein Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Primers - genetics Female gene dosage Gene Expression - genetics Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Middle Aged mRNA Multivariate Analysis Mutation, Missense - genetics Nerve Tissue Proteins - genetics Nervous system (semeiology, syndromes) Neurology Parkinson Disease - genetics Parkinson's disease Polymerase Chain Reaction RNA, Messenger - genetics Synucleins |
| title | Alpha-synuclein mRNA expression in sporadic Parkinson's disease |
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