Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

Patients with Alzheimer's disease suffer from progressive cognitive impairments and show distinct post-mortem neuropathology, including β-amyloid plaques. Transgenic (Tg) CRND8 mice carry a mutated human amyloid precursor protein gene and show age-related increases in β-amyloid production and p...

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Veröffentlicht in:	Behavioural brain research 2005-05, Vol.160 (2), p.344-355
Hauptverfasser:	Hyde, Lynn A., Kazdoba, Tatiana M., Grilli, Mariagrazia, Lozza, Gianluca, Brussa, Rosella, Zhang, Qi, Wong, Gwendolyn T., McCool, Martha F., Zhang, Lili, Parker, Eric M., Higgins, Guy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging - physiology Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid burden Analysis of Variance Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences Brain - metabolism Brain - pathology Cognition Disorders - genetics Cognition Disorders - metabolism Cognition Disorders - pathology Cognition Disorders - physiopathology Diagnostic Imaging - methods Female Fundamental and applied biological sciences. Psychology Immunohistochemistry Immunohistochemistry - methods Locomotor activity Male Maze Learning - physiology Memory, Short-Term - physiology Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity - physiology Novelty Open field Plaque, Amyloid - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - physiology Recognition Reference memory Rota-rod Sandwich immunoassay Spatial Behavior - physiology
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