Scintigraphic Imaging of Infectious Foci with an 111In-LTB4 Antagonist Is Based on In Vivo Labeling of Granulocytes

Radiolabeled leukotriene B4 (LTB4) antagonist DPC11870 is able to reveal infectious and inflammatory foci in distinct animal models. Because previous studies showed that accumulation of (111)In-DPC11870 in the abscess continued although the tracer had cleared from the circulation, we decided to inve...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2005-05, Vol.46 (5), p.786-793
Hauptverfasser:	van Eerd, Julliette E.M, Oyen, Wim J.G, Harris, Thomas D, Rennen, Huub J.J.M, Edwards, D. Scott, Corstens, Frans H.M, Boerman, Otto C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biphenyl Compounds - pharmacokinetics Escherichia coli Infections - diagnostic imaging Escherichia coli Infections - metabolism Female Granulocytes - diagnostic imaging Leukotriene B4 - antagonists & inhibitors Metabolic Clearance Rate Oligopeptides - pharmacokinetics Organ Specificity Pyridines - pharmacokinetics Rabbits Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Tetrazoles - pharmacokinetics Tissue Distribution Whole-Body Counting
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