Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes: Possible regenerative roles in articular cartilage metabolism

It is known that expression of the macrophage colony-stimulating factor (M-CSF) gene is induced in articular chondrocytes upon inflammation. However, the functional role of M-CSF in cartilage has been unclear. In this study, we describe possible roles of M-CSF in the protection and maintenance of th...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2005-05, Vol.36 (5), p.884-892
Hauptverfasser:	Nakao, Kyouji, Kubota, Satoshi, Doi, Hideyuki, Eguchi, Takanori, Oka, Morihiko, Fujisawa, Takuo, Nishida, Takashi, Takigawa, Masaharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Cartilage, Articular - physiology CCN family Cell Line Chondrocytes Chondrocytes - physiology Connective Tissue Growth Factor Connective tissue growth factor (CTGF) DNA Primers Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Immediate-Early Proteins - physiology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - physiology M-CSF Macrophage Colony-Stimulating Factor - genetics Macrophage Colony-Stimulating Factor - metabolism Macrophage Colony-Stimulating Factor - physiology Osteoarthritis - metabolism Proteoglycans - biosynthesis Recombinant Proteins - metabolism Regeneration Vertebrates: anatomy and physiology, studies on body, several organs or systems
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