HLA‐DRB1 alleles in Hb SS patients with avascular necrosis of the femoral head
Strong associations have been established between various HLA alleles and different complications of sickle cell disease (SCD). Recently, the HLA‐DRB1*03 allele was shown to be associated with susceptibility to stroke while the HLA‐DRB1*02 allele may be protective. While stroke and silent brain infa...
Gespeichert in:
| Veröffentlicht in: | American journal of hematology 2005-05, Vol.79 (1), p.8-10 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10 |
|---|---|
| container_issue | 1 |
| container_start_page | 8 |
| container_title | American journal of hematology |
| container_volume | 79 |
| creator | Adekile, A. Haider, M.Z. Marouf, R. Adekile, A.D. |
| description | Strong associations have been established between various HLA alleles and different complications of sickle cell disease (SCD). Recently, the HLA‐DRB1*03 allele was shown to be associated with susceptibility to stroke while the HLA‐DRB1*02 allele may be protective. While stroke and silent brain infarcts (SBI) are unusual in Kuwaiti children with SCD, avascular necrosis of the femoral head (AVNFH) is quite common. The modulatory association factors must still be elucidated. An investigation of HLA‐DRB1 alleles was carried out in a group of 68 Kuwaiti SS patients, of age 7–44 years, of whom 20 (29.4%) had AVNFH, confirmed by magnetic resonance imaging. A group of 167 apparently healthy age‐ and sex‐matched individuals served as controls. Comparison of the HLA alleles between the whole SS group and the controls showed a significant over‐representation of DRB1*01 (P < 0.01) and DRB1*10 (P < 0.05) in the patient group. No significant differences in the allele frequencies in the SS patients with or without AVNFH were observed. It therefore appears that the HLA‐DRB1 locus does not play a significant role in the pathogenesis of AVNFH Kuwaiti patients. Am. J. Hematol. 79:8–10, 2005. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajh.20311 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67798632</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67798632</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3881-203a7580486ffae41091f03c7446b188dc051b19ed89382f7724dee2def79eae3</originalsourceid><addsrcrecordid>eNp1kM1Og0AUhSdGY2t14QuY2WjignZ-gBmWtf6gaaKxuiYD3Ak0U6gM2HTnI_iMPolUSLpyde_iyzknH0LnlIwpIWyiltmYEU7pARpSEviO9D12iIaE-7T9STBAJ9YuCaHUleQYDagn3UAIb4hewvn05-v79vWGYmUMGLA4L3AY48UCr1WdQ1FbvMnrDKtPZZPGqAoXkFSlzS0uNa4zwBpWZaUMzkClp-hIK2PhrL8j9H5_9zYLnfnzw-NsOncSLiV12rlKeJK40tdagdvOpprwRLiuH1Mp04R4NKYBpDLgkmkhmJsCsBS0CEABH6GrLnddlR8N2Dpa5TYBY1QBZWMjX4hA-py14HUH7jbbCnS0rvKVqrYRJdFOX9Tqi_70texFH9rEK0j3ZO-rBS57oHWhjK5UkeR2z_nC5ZztuEnHbXID2_8bo-lT2FX_AkXvhQs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67798632</pqid></control><display><type>article</type><title>HLA‐DRB1 alleles in Hb SS patients with avascular necrosis of the femoral head</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Adekile, A. ; Haider, M.Z. ; Marouf, R. ; Adekile, A.D.</creator><creatorcontrib>Adekile, A. ; Haider, M.Z. ; Marouf, R. ; Adekile, A.D.</creatorcontrib><description>Strong associations have been established between various HLA alleles and different complications of sickle cell disease (SCD). Recently, the HLA‐DRB1*03 allele was shown to be associated with susceptibility to stroke while the HLA‐DRB1*02 allele may be protective. While stroke and silent brain infarcts (SBI) are unusual in Kuwaiti children with SCD, avascular necrosis of the femoral head (AVNFH) is quite common. The modulatory association factors must still be elucidated. An investigation of HLA‐DRB1 alleles was carried out in a group of 68 Kuwaiti SS patients, of age 7–44 years, of whom 20 (29.4%) had AVNFH, confirmed by magnetic resonance imaging. A group of 167 apparently healthy age‐ and sex‐matched individuals served as controls. Comparison of the HLA alleles between the whole SS group and the controls showed a significant over‐representation of DRB1*01 (P < 0.01) and DRB1*10 (P < 0.05) in the patient group. No significant differences in the allele frequencies in the SS patients with or without AVNFH were observed. It therefore appears that the HLA‐DRB1 locus does not play a significant role in the pathogenesis of AVNFH Kuwaiti patients. Am. J. Hematol. 79:8–10, 2005. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.20311</identifier><identifier>PMID: 15849775</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; avascular necrosis ; Biological and medical sciences ; Child ; Diseases of the osteoarticular system ; femoral head ; Femur Head Necrosis - genetics ; Genetic Predisposition to Disease ; Hb SS ; Hematologic and hematopoietic diseases ; Hemoglobin, Sickle - genetics ; HLA-DR Antigens - genetics ; HLA-DRB1 Chains ; HLA‐DRB1 ; Humans ; Kuwait ; Magnetic Resonance Imaging ; Medical sciences ; Stroke - genetics ; Vascular bone diseases</subject><ispartof>American journal of hematology, 2005-05, Vol.79 (1), p.8-10</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc., A Wiley Company</rights><rights>2005 INIST-CNRS</rights><rights>2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-203a7580486ffae41091f03c7446b188dc051b19ed89382f7724dee2def79eae3</citedby><cites>FETCH-LOGICAL-c3881-203a7580486ffae41091f03c7446b188dc051b19ed89382f7724dee2def79eae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.20311$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.20311$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16743325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15849775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adekile, A.</creatorcontrib><creatorcontrib>Haider, M.Z.</creatorcontrib><creatorcontrib>Marouf, R.</creatorcontrib><creatorcontrib>Adekile, A.D.</creatorcontrib><title>HLA‐DRB1 alleles in Hb SS patients with avascular necrosis of the femoral head</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>Strong associations have been established between various HLA alleles and different complications of sickle cell disease (SCD). Recently, the HLA‐DRB1*03 allele was shown to be associated with susceptibility to stroke while the HLA‐DRB1*02 allele may be protective. While stroke and silent brain infarcts (SBI) are unusual in Kuwaiti children with SCD, avascular necrosis of the femoral head (AVNFH) is quite common. The modulatory association factors must still be elucidated. An investigation of HLA‐DRB1 alleles was carried out in a group of 68 Kuwaiti SS patients, of age 7–44 years, of whom 20 (29.4%) had AVNFH, confirmed by magnetic resonance imaging. A group of 167 apparently healthy age‐ and sex‐matched individuals served as controls. Comparison of the HLA alleles between the whole SS group and the controls showed a significant over‐representation of DRB1*01 (P < 0.01) and DRB1*10 (P < 0.05) in the patient group. No significant differences in the allele frequencies in the SS patients with or without AVNFH were observed. It therefore appears that the HLA‐DRB1 locus does not play a significant role in the pathogenesis of AVNFH Kuwaiti patients. Am. J. Hematol. 79:8–10, 2005. © 2005 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>avascular necrosis</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Diseases of the osteoarticular system</subject><subject>femoral head</subject><subject>Femur Head Necrosis - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Hb SS</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobin, Sickle - genetics</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DRB1 Chains</subject><subject>HLA‐DRB1</subject><subject>Humans</subject><subject>Kuwait</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Stroke - genetics</subject><subject>Vascular bone diseases</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1Og0AUhSdGY2t14QuY2WjignZ-gBmWtf6gaaKxuiYD3Ak0U6gM2HTnI_iMPolUSLpyde_iyzknH0LnlIwpIWyiltmYEU7pARpSEviO9D12iIaE-7T9STBAJ9YuCaHUleQYDagn3UAIb4hewvn05-v79vWGYmUMGLA4L3AY48UCr1WdQ1FbvMnrDKtPZZPGqAoXkFSlzS0uNa4zwBpWZaUMzkClp-hIK2PhrL8j9H5_9zYLnfnzw-NsOncSLiV12rlKeJK40tdagdvOpprwRLiuH1Mp04R4NKYBpDLgkmkhmJsCsBS0CEABH6GrLnddlR8N2Dpa5TYBY1QBZWMjX4hA-py14HUH7jbbCnS0rvKVqrYRJdFOX9Tqi_70texFH9rEK0j3ZO-rBS57oHWhjK5UkeR2z_nC5ZztuEnHbXID2_8bo-lT2FX_AkXvhQs</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Adekile, A.</creator><creator>Haider, M.Z.</creator><creator>Marouf, R.</creator><creator>Adekile, A.D.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200505</creationdate><title>HLA‐DRB1 alleles in Hb SS patients with avascular necrosis of the femoral head</title><author>Adekile, A. ; Haider, M.Z. ; Marouf, R. ; Adekile, A.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-203a7580486ffae41091f03c7446b188dc051b19ed89382f7724dee2def79eae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>avascular necrosis</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Diseases of the osteoarticular system</topic><topic>femoral head</topic><topic>Femur Head Necrosis - genetics</topic><topic>Genetic Predisposition to Disease</topic><topic>Hb SS</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobin, Sickle - genetics</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DRB1 Chains</topic><topic>HLA‐DRB1</topic><topic>Humans</topic><topic>Kuwait</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Stroke - genetics</topic><topic>Vascular bone diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adekile, A.</creatorcontrib><creatorcontrib>Haider, M.Z.</creatorcontrib><creatorcontrib>Marouf, R.</creatorcontrib><creatorcontrib>Adekile, A.D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adekile, A.</au><au>Haider, M.Z.</au><au>Marouf, R.</au><au>Adekile, A.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA‐DRB1 alleles in Hb SS patients with avascular necrosis of the femoral head</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2005-05</date><risdate>2005</risdate><volume>79</volume><issue>1</issue><spage>8</spage><epage>10</epage><pages>8-10</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Strong associations have been established between various HLA alleles and different complications of sickle cell disease (SCD). Recently, the HLA‐DRB1*03 allele was shown to be associated with susceptibility to stroke while the HLA‐DRB1*02 allele may be protective. While stroke and silent brain infarcts (SBI) are unusual in Kuwaiti children with SCD, avascular necrosis of the femoral head (AVNFH) is quite common. The modulatory association factors must still be elucidated. An investigation of HLA‐DRB1 alleles was carried out in a group of 68 Kuwaiti SS patients, of age 7–44 years, of whom 20 (29.4%) had AVNFH, confirmed by magnetic resonance imaging. A group of 167 apparently healthy age‐ and sex‐matched individuals served as controls. Comparison of the HLA alleles between the whole SS group and the controls showed a significant over‐representation of DRB1*01 (P < 0.01) and DRB1*10 (P < 0.05) in the patient group. No significant differences in the allele frequencies in the SS patients with or without AVNFH were observed. It therefore appears that the HLA‐DRB1 locus does not play a significant role in the pathogenesis of AVNFH Kuwaiti patients. Am. J. Hematol. 79:8–10, 2005. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15849775</pmid><doi>10.1002/ajh.20311</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-8609 |
| ispartof | American journal of hematology, 2005-05, Vol.79 (1), p.8-10 |
| issn | 0361-8609 1096-8652 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67798632 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult avascular necrosis Biological and medical sciences Child Diseases of the osteoarticular system femoral head Femur Head Necrosis - genetics Genetic Predisposition to Disease Hb SS Hematologic and hematopoietic diseases Hemoglobin, Sickle - genetics HLA-DR Antigens - genetics HLA-DRB1 Chains HLA‐DRB1 Humans Kuwait Magnetic Resonance Imaging Medical sciences Stroke - genetics Vascular bone diseases |
| title | HLA‐DRB1 alleles in Hb SS patients with avascular necrosis of the femoral head |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T22%3A44%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HLA%E2%80%90DRB1%20alleles%20in%20Hb%20SS%20patients%20with%20avascular%20necrosis%20of%20the%20femoral%20head&rft.jtitle=American%20journal%20of%20hematology&rft.au=Adekile,%20A.&rft.date=2005-05&rft.volume=79&rft.issue=1&rft.spage=8&rft.epage=10&rft.pages=8-10&rft.issn=0361-8609&rft.eissn=1096-8652&rft.coden=AJHEDD&rft_id=info:doi/10.1002/ajh.20311&rft_dat=%3Cproquest_cross%3E67798632%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67798632&rft_id=info:pmid/15849775&rfr_iscdi=true |