Viral double-stranded RNA aggravates lupus nephritis through toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells

How viral infections trigger autoimmunity is poorly understood. A role for Toll-like receptor 3 (TLR3) was hypothesized in this context as viral double-stranded RNA (dsRNA) activates dendritic cells to secrete type I interferons and cytokines that are known to be associated with the disease activity...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2005-05, Vol.16 (5), p.1326-1338
Hauptverfasser:	PATOLE, Prashant S, GRÖNE, Hermann-Josef, SEGERER, Stephan, CIUBAR, Raluca, BELEMEZOVA, Emilia, HENGER, Anna, KRETZLER, Matthias, SCHLÖNDORFF, Detlef, ANDERS, Hans-Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology Antigen-Presenting Cells - virology Autoantibodies - immunology B-Lymphocytes - immunology Biological and medical sciences Cells, Cultured Chemokine CCL2 - secretion Chemokines, CC - blood Female Glomerular Mesangium - immunology Glomerular Mesangium - metabolism Glomerular Mesangium - secretion Inflammation Mediators - immunology Injections, Intravenous Interferon-alpha - blood Interleukin-12 - blood Interleukin-6 - blood Interleukin-6 - secretion Kidneys Lupus Nephritis - immunology Lupus Nephritis - virology Medical sciences Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred MRL lpr Nephrology. Urinary tract diseases Picornaviridae Infections - complications Picornaviridae Infections - immunology Protein Subunits - blood Proteinuria - immunology Proteinuria - virology Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Rhinovirus - genetics RNA, Double-Stranded - immunology RNA, Viral - immunology RNA, Viral - pharmacology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Toll-Like Receptor 3 Toll-Like Receptors Urinary system involvement in other diseases. Miscellaneous
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