Stereoselective metabolism of rabeprazole-thioether to rabeprazole by human liver microsomes

Rabeprazole is metabolized mainly non-enzymatically to rabeprazole-thioether. This in vitro study was designed to clarify the stereoselective oxidation mechanism and to identify the enzyme(s) involved in the metabolic breakdown of rabeprazole-thioether to rabeprazole. Rabeprazole-thioether was incub...

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Veröffentlicht in:	European journal of clinical pharmacology 2006-02, Vol.62 (2), p.113-117
Hauptverfasser:	MIURA, Masatomo, SATOH, Shigeru, TADA, Hitoshi, HABUCHI, Tomonori, SUZUKI, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles - metabolism Area Under Curve Biological and medical sciences Chromatography, High Pressure Liquid - methods Cytochrome P-450 Enzyme System - metabolism Humans In Vitro Techniques Medical sciences Microsomes, Liver - enzymology Pharmacology. Drug treatments Proton Pump Inhibitors Rabeprazole Stereoisomerism Sulfides - metabolism
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