Synthesis, characterization, and biological activity of oxovanadium(IV) complexes with polyalcohols
Oxovanadium(IV) complexes of the polyalcohols sorbitol, galactitol, and mannitol, of stoichiometry Na 2[VO(L) 2]·H 2O, were obtained from aqueous alkaline solutions. They were characterized by elemental analysis, infrared and UV–vis spectroscopies, thermoanalytical (thermogravimetric and differentia...
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| Veröffentlicht in: | Carbohydrate research 2006-05, Vol.341 (6), p.717-724 |
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| container_title | Carbohydrate research |
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| creator | Williams, Patricia A.M. Etcheverry, Susana B. Barrio, Daniel A. Baran, Enrique J. |
| description | Oxovanadium(IV) complexes of the polyalcohols sorbitol, galactitol, and mannitol, of stoichiometry Na
2[VO(L)
2]·H
2O, were obtained from aqueous alkaline solutions. They were characterized by elemental analysis, infrared and UV–vis spectroscopies, thermoanalytical (thermogravimetric and differential thermal analysis) data, and magnetic susceptibility measurements. The biological activities of the complexes on the proliferation, differentiation, and glucose consumption were tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The three complexes exerted a biphasic effect on cell proliferation, being slight stimulating agents at low concentrations and inhibitory in the range of 25–100
μM. All the complexes inhibited cell differentiation in tumor osteoblasts. Their effects on glucose consumption were also discussed. The free ligands did not show any effect on the studied biological parameters. |
| doi_str_mv | 10.1016/j.carres.2006.01.009 |
| format | Article |
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2[VO(L)
2]·H
2O, were obtained from aqueous alkaline solutions. They were characterized by elemental analysis, infrared and UV–vis spectroscopies, thermoanalytical (thermogravimetric and differential thermal analysis) data, and magnetic susceptibility measurements. The biological activities of the complexes on the proliferation, differentiation, and glucose consumption were tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The three complexes exerted a biphasic effect on cell proliferation, being slight stimulating agents at low concentrations and inhibitory in the range of 25–100
μM. All the complexes inhibited cell differentiation in tumor osteoblasts. Their effects on glucose consumption were also discussed. The free ligands did not show any effect on the studied biological parameters.</description><identifier>ISSN: 0008-6215</identifier><identifier>EISSN: 1873-426X</identifier><identifier>DOI: 10.1016/j.carres.2006.01.009</identifier><identifier>PMID: 16458276</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Alcohols - chemistry ; Animals ; Cell Proliferation ; Cells in culture ; Cells, Cultured ; Galactitol ; Hot Temperature ; Infrared Rays ; Mannitol ; Mice ; Molecular Structure ; Osteoblasts ; Oxovanadium(IV) complexes ; Sorbitol ; Tumor Cells, Cultured ; Vanadium Compounds - chemical synthesis ; Vanadium Compounds - chemistry</subject><ispartof>Carbohydrate research, 2006-05, Vol.341 (6), p.717-724</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-9abfac70d638ba4be8b35e6a690d328dbed039649b32dc21870e37eff06bf8743</citedby><cites>FETCH-LOGICAL-c360t-9abfac70d638ba4be8b35e6a690d328dbed039649b32dc21870e37eff06bf8743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carres.2006.01.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16458276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Patricia A.M.</creatorcontrib><creatorcontrib>Etcheverry, Susana B.</creatorcontrib><creatorcontrib>Barrio, Daniel A.</creatorcontrib><creatorcontrib>Baran, Enrique J.</creatorcontrib><title>Synthesis, characterization, and biological activity of oxovanadium(IV) complexes with polyalcohols</title><title>Carbohydrate research</title><addtitle>Carbohydr Res</addtitle><description>Oxovanadium(IV) complexes of the polyalcohols sorbitol, galactitol, and mannitol, of stoichiometry Na
2[VO(L)
2]·H
2O, were obtained from aqueous alkaline solutions. They were characterized by elemental analysis, infrared and UV–vis spectroscopies, thermoanalytical (thermogravimetric and differential thermal analysis) data, and magnetic susceptibility measurements. The biological activities of the complexes on the proliferation, differentiation, and glucose consumption were tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The three complexes exerted a biphasic effect on cell proliferation, being slight stimulating agents at low concentrations and inhibitory in the range of 25–100
μM. All the complexes inhibited cell differentiation in tumor osteoblasts. Their effects on glucose consumption were also discussed. The free ligands did not show any effect on the studied biological parameters.</description><subject>Alcohols - chemistry</subject><subject>Animals</subject><subject>Cell Proliferation</subject><subject>Cells in culture</subject><subject>Cells, Cultured</subject><subject>Galactitol</subject><subject>Hot Temperature</subject><subject>Infrared Rays</subject><subject>Mannitol</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>Osteoblasts</subject><subject>Oxovanadium(IV) complexes</subject><subject>Sorbitol</subject><subject>Tumor Cells, Cultured</subject><subject>Vanadium Compounds - chemical synthesis</subject><subject>Vanadium Compounds - chemistry</subject><issn>0008-6215</issn><issn>1873-426X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFuLFDEQhYMo7rj6D0TyJArbbaXTU-l-EWTxsrDggxd8C7lUOxnSnTHpGXf89fYyA775VBR1zinOx9hzAbUAgW-2tTM5U6kbAKxB1AD9A7YSnZJV2-CPh2wFAF2FjVhfsCelbJcVUOFjdiGwXXeNwhVzX47TvKESyhV3G5ONmymHP2YOabriZvLchhTTz-BM5MsxHMJ85Gng6S4dzGR82I-vbr6_5i6Nu0h3VPjvMG_4LsWjiS5tUixP2aPBxELPzvOSffvw_uv1p-r288eb63e3lZMIc9UbOxinwKPsrGktdVauCQ324GXTeUseZI9tb2XjXbMUBZKKhgHQDp1q5SV7ecrd5fRrT2XWYyiOYjQTpX3RqFSvENeLsD0JXU6lZBr0LofR5KMWoO_h6q0-wdX3cDUIvcBdbC_O-Xs7kv9nOtNcBG9PAlpaHgJlXVygyZEPmdysfQr___AXCEKPZw</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Williams, Patricia A.M.</creator><creator>Etcheverry, Susana B.</creator><creator>Barrio, Daniel A.</creator><creator>Baran, Enrique J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Synthesis, characterization, and biological activity of oxovanadium(IV) complexes with polyalcohols</title><author>Williams, Patricia A.M. ; Etcheverry, Susana B. ; Barrio, Daniel A. ; Baran, Enrique J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-9abfac70d638ba4be8b35e6a690d328dbed039649b32dc21870e37eff06bf8743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alcohols - chemistry</topic><topic>Animals</topic><topic>Cell Proliferation</topic><topic>Cells in culture</topic><topic>Cells, Cultured</topic><topic>Galactitol</topic><topic>Hot Temperature</topic><topic>Infrared Rays</topic><topic>Mannitol</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>Osteoblasts</topic><topic>Oxovanadium(IV) complexes</topic><topic>Sorbitol</topic><topic>Tumor Cells, Cultured</topic><topic>Vanadium Compounds - chemical synthesis</topic><topic>Vanadium Compounds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Patricia A.M.</creatorcontrib><creatorcontrib>Etcheverry, Susana B.</creatorcontrib><creatorcontrib>Barrio, Daniel A.</creatorcontrib><creatorcontrib>Baran, Enrique J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Patricia A.M.</au><au>Etcheverry, Susana B.</au><au>Barrio, Daniel A.</au><au>Baran, Enrique J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization, and biological activity of oxovanadium(IV) complexes with polyalcohols</atitle><jtitle>Carbohydrate research</jtitle><addtitle>Carbohydr Res</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>341</volume><issue>6</issue><spage>717</spage><epage>724</epage><pages>717-724</pages><issn>0008-6215</issn><eissn>1873-426X</eissn><abstract>Oxovanadium(IV) complexes of the polyalcohols sorbitol, galactitol, and mannitol, of stoichiometry Na
2[VO(L)
2]·H
2O, were obtained from aqueous alkaline solutions. They were characterized by elemental analysis, infrared and UV–vis spectroscopies, thermoanalytical (thermogravimetric and differential thermal analysis) data, and magnetic susceptibility measurements. The biological activities of the complexes on the proliferation, differentiation, and glucose consumption were tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The three complexes exerted a biphasic effect on cell proliferation, being slight stimulating agents at low concentrations and inhibitory in the range of 25–100
μM. All the complexes inhibited cell differentiation in tumor osteoblasts. Their effects on glucose consumption were also discussed. The free ligands did not show any effect on the studied biological parameters.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>16458276</pmid><doi>10.1016/j.carres.2006.01.009</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alcohols - chemistry Animals Cell Proliferation Cells in culture Cells, Cultured Galactitol Hot Temperature Infrared Rays Mannitol Mice Molecular Structure Osteoblasts Oxovanadium(IV) complexes Sorbitol Tumor Cells, Cultured Vanadium Compounds - chemical synthesis Vanadium Compounds - chemistry |
| title | Synthesis, characterization, and biological activity of oxovanadium(IV) complexes with polyalcohols |
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