Role of Glutamate and Dopamine Receptors in the Psychopharmacological Profile of the Indole Alkaloid Psychollatine
Psychollatine (1), a new glycoside indole monoterpene alkaloid isolated from Psychotria umbellata, has shown an interesting psychopharmacological profile. This study aimed to investigate the role of NMDA glutamate and dopamine receptors in mediating the properties of 1. Psychollatine (1) was assesse...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2006-03, Vol.69 (3), p.342-345 |
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| creator | Both, Fernanda L Meneghini, Lisiane Kerber, Vitor A Henriques, Amélia T Elisabetsky, Elaine |
| description | Psychollatine (1), a new glycoside indole monoterpene alkaloid isolated from Psychotria umbellata, has shown an interesting psychopharmacological profile. This study aimed to investigate the role of NMDA glutamate and dopamine receptors in mediating the properties of 1. Psychollatine (1) was assessed for NMDA-induced seizures, MK-801-induced hyperlocomotion, amphetamine-induced lethality, and apomorphine-induced climbing behavior in mice. Psychollatine (1) (100 mg/kg) and MK-801 (0.3 mg/kg) prevented NMDA-induced seizures (P < 0.01), while 1 (100 mg/kg) attenuated the MK-801-induced hyperlocomotion (P < 0.05). Compound 1 (3 and 10 mg/kg), as well as chlorpromazine (4 mg/kg), prevented amphetamine-induced lethality (P < 0.05). Finally, 1 (10 mg/kg) (P < 0.05), MK-801 (0.2 mg/kg) (P < 0.01), and chlorpromazine (4 mg/kg) (P < 0.01) attenuated apomorphine-induced climbing behavior. The present results strongly support the involvement of NMDA glutamate receptors in the mode of action of psychollatine (1). |
| doi_str_mv | 10.1021/np050291v |
| format | Article |
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This study aimed to investigate the role of NMDA glutamate and dopamine receptors in mediating the properties of 1. Psychollatine (1) was assessed for NMDA-induced seizures, MK-801-induced hyperlocomotion, amphetamine-induced lethality, and apomorphine-induced climbing behavior in mice. Psychollatine (1) (100 mg/kg) and MK-801 (0.3 mg/kg) prevented NMDA-induced seizures (P < 0.01), while 1 (100 mg/kg) attenuated the MK-801-induced hyperlocomotion (P < 0.05). Compound 1 (3 and 10 mg/kg), as well as chlorpromazine (4 mg/kg), prevented amphetamine-induced lethality (P < 0.05). Finally, 1 (10 mg/kg) (P < 0.05), MK-801 (0.2 mg/kg) (P < 0.01), and chlorpromazine (4 mg/kg) (P < 0.01) attenuated apomorphine-induced climbing behavior. The present results strongly support the involvement of NMDA glutamate receptors in the mode of action of psychollatine (1).]]></description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np050291v</identifier><identifier>PMID: 16562831</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>amphetamine ; Amphetamine - pharmacology ; Animals ; Antipsychotic Agents - chemistry ; Antipsychotic Agents - isolation & purification ; Antipsychotic Agents - pharmacology ; apomorphine ; Apomorphine - pharmacology ; Biological and medical sciences ; Brazil ; Chlorpromazine - pharmacology ; Diazepam - pharmacology ; Dizocilpine Maleate - pharmacology ; dopamine ; dopamine receptor ; General pharmacology ; glutamate receptor ; glutamic acid ; glycosides ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; indole alkaloids ; Indole Alkaloids - chemistry ; Indole Alkaloids - isolation & purification ; Indole Alkaloids - pharmacology ; Male ; Medical sciences ; Memory - drug effects ; Mice ; Models, Biological ; Molecular Structure ; monoterpenoids ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry ; psychollatine ; Psychopharmacology ; Psychotria ; Psychotria - chemistry ; Psychotria umbellata ; receptors ; Receptors, Dopamine - physiology ; Receptors, GABA-A - drug effects ; Receptors, N-Methyl-D-Aspartate - physiology ; Receptors, Serotonin - drug effects ; Rubiaceae ; seizures ; Serotonin Receptor Agonists - pharmacology ; signal transduction</subject><ispartof>Journal of natural products (Washington, D.C.), 2006-03, Vol.69 (3), p.342-345</ispartof><rights>Copyright © 2006 American Chemical Society and American Society of Pharmacognosy</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a351t-38e0e7dd2ee830d92574bc47ba25ae04f5b6369440fa40b6b08349759071d1bb3</citedby><cites>FETCH-LOGICAL-a351t-38e0e7dd2ee830d92574bc47ba25ae04f5b6369440fa40b6b08349759071d1bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np050291v$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np050291v$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27074,27922,27923,56736,56786</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17664575$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16562831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Both, Fernanda L</creatorcontrib><creatorcontrib>Meneghini, Lisiane</creatorcontrib><creatorcontrib>Kerber, Vitor A</creatorcontrib><creatorcontrib>Henriques, Amélia T</creatorcontrib><creatorcontrib>Elisabetsky, Elaine</creatorcontrib><title>Role of Glutamate and Dopamine Receptors in the Psychopharmacological Profile of the Indole Alkaloid Psychollatine</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description><![CDATA[Psychollatine (1), a new glycoside indole monoterpene alkaloid isolated from Psychotria umbellata, has shown an interesting psychopharmacological profile. This study aimed to investigate the role of NMDA glutamate and dopamine receptors in mediating the properties of 1. Psychollatine (1) was assessed for NMDA-induced seizures, MK-801-induced hyperlocomotion, amphetamine-induced lethality, and apomorphine-induced climbing behavior in mice. Psychollatine (1) (100 mg/kg) and MK-801 (0.3 mg/kg) prevented NMDA-induced seizures (P < 0.01), while 1 (100 mg/kg) attenuated the MK-801-induced hyperlocomotion (P < 0.05). Compound 1 (3 and 10 mg/kg), as well as chlorpromazine (4 mg/kg), prevented amphetamine-induced lethality (P < 0.05). Finally, 1 (10 mg/kg) (P < 0.05), MK-801 (0.2 mg/kg) (P < 0.01), and chlorpromazine (4 mg/kg) (P < 0.01) attenuated apomorphine-induced climbing behavior. The present results strongly support the involvement of NMDA glutamate receptors in the mode of action of psychollatine (1).]]></description><subject>amphetamine</subject><subject>Amphetamine - pharmacology</subject><subject>Animals</subject><subject>Antipsychotic Agents - chemistry</subject><subject>Antipsychotic Agents - isolation & purification</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>apomorphine</subject><subject>Apomorphine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Chlorpromazine - pharmacology</subject><subject>Diazepam - pharmacology</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>dopamine</subject><subject>dopamine receptor</subject><subject>General pharmacology</subject><subject>glutamate receptor</subject><subject>glutamic acid</subject><subject>glycosides</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>indole alkaloids</subject><subject>Indole Alkaloids - chemistry</subject><subject>Indole Alkaloids - isolation & purification</subject><subject>Indole Alkaloids - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Molecular Structure</subject><subject>monoterpenoids</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>psychollatine</subject><subject>Psychopharmacology</subject><subject>Psychotria</subject><subject>Psychotria - chemistry</subject><subject>Psychotria umbellata</subject><subject>receptors</subject><subject>Receptors, Dopamine - physiology</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Receptors, N-Methyl-D-Aspartate - physiology</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Rubiaceae</subject><subject>seizures</subject><subject>Serotonin Receptor Agonists - pharmacology</subject><subject>signal transduction</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1v1DAQBmALgehSOPAHIBeQOATG38mxWqCttIjVtlWP1iRxummTONgJov8erxJ1L0icfPAzrz0zhLyl8JkCo1_6ASSwnP5-RlZUMkgVMPmcrIAqnvJMiRPyKoR7AOCQy5fkhCqpWMbpivida23i6uS8nUbscLQJ9lXy1Q3YNb1Ndra0w-h8SJo-Gfc22YbHcu-GPfoOS9e6u6bENtl6Vzdz0AFd9tUh9qx9wNY11VLUtjjGzNfkRY1tsG-W85TcfP92vb5INz_PL9dnmxS5pGP8twWrq4pZm3Gocia1KEqhC2QSLYhaFoqrXAioUUChCsi4yLXMQdOKFgU_JR_n3MG7X5MNo-maUNr4i966KRilda5jxX8hzTmjNBMRfpph6V0I3tZm8E2H_tFQMIdNmKdNRPtuCZ2KzlZHuYw-gg8LwBBHWHvsyyYcnVZKSC2jS2fXhNH-ebpH_xA74Fqa6-2V2d3CenP7IzMX0b-ffY3O4J2PmTdXDCgHCrlSUh5fxjKYezf5Pq7hHy38BYHYtSg</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Both, Fernanda L</creator><creator>Meneghini, Lisiane</creator><creator>Kerber, Vitor A</creator><creator>Henriques, Amélia T</creator><creator>Elisabetsky, Elaine</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>Role of Glutamate and Dopamine Receptors in the Psychopharmacological Profile of the Indole Alkaloid Psychollatine</title><author>Both, Fernanda L ; Meneghini, Lisiane ; Kerber, Vitor A ; Henriques, Amélia T ; Elisabetsky, Elaine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a351t-38e0e7dd2ee830d92574bc47ba25ae04f5b6369440fa40b6b08349759071d1bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>amphetamine</topic><topic>Amphetamine - pharmacology</topic><topic>Animals</topic><topic>Antipsychotic Agents - chemistry</topic><topic>Antipsychotic Agents - isolation & purification</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>apomorphine</topic><topic>Apomorphine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Chlorpromazine - pharmacology</topic><topic>Diazepam - pharmacology</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>dopamine</topic><topic>dopamine receptor</topic><topic>General pharmacology</topic><topic>glutamate receptor</topic><topic>glutamic acid</topic><topic>glycosides</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>indole alkaloids</topic><topic>Indole Alkaloids - chemistry</topic><topic>Indole Alkaloids - isolation & purification</topic><topic>Indole Alkaloids - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Molecular Structure</topic><topic>monoterpenoids</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>psychollatine</topic><topic>Psychopharmacology</topic><topic>Psychotria</topic><topic>Psychotria - chemistry</topic><topic>Psychotria umbellata</topic><topic>receptors</topic><topic>Receptors, Dopamine - physiology</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Receptors, N-Methyl-D-Aspartate - physiology</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Rubiaceae</topic><topic>seizures</topic><topic>Serotonin Receptor Agonists - pharmacology</topic><topic>signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Both, Fernanda L</creatorcontrib><creatorcontrib>Meneghini, Lisiane</creatorcontrib><creatorcontrib>Kerber, Vitor A</creatorcontrib><creatorcontrib>Henriques, Amélia T</creatorcontrib><creatorcontrib>Elisabetsky, Elaine</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Both, Fernanda L</au><au>Meneghini, Lisiane</au><au>Kerber, Vitor A</au><au>Henriques, Amélia T</au><au>Elisabetsky, Elaine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Glutamate and Dopamine Receptors in the Psychopharmacological Profile of the Indole Alkaloid Psychollatine</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2006-03</date><risdate>2006</risdate><volume>69</volume><issue>3</issue><spage>342</spage><epage>345</epage><pages>342-345</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract><![CDATA[Psychollatine (1), a new glycoside indole monoterpene alkaloid isolated from Psychotria umbellata, has shown an interesting psychopharmacological profile. This study aimed to investigate the role of NMDA glutamate and dopamine receptors in mediating the properties of 1. Psychollatine (1) was assessed for NMDA-induced seizures, MK-801-induced hyperlocomotion, amphetamine-induced lethality, and apomorphine-induced climbing behavior in mice. Psychollatine (1) (100 mg/kg) and MK-801 (0.3 mg/kg) prevented NMDA-induced seizures (P < 0.01), while 1 (100 mg/kg) attenuated the MK-801-induced hyperlocomotion (P < 0.05). Compound 1 (3 and 10 mg/kg), as well as chlorpromazine (4 mg/kg), prevented amphetamine-induced lethality (P < 0.05). Finally, 1 (10 mg/kg) (P < 0.05), MK-801 (0.2 mg/kg) (P < 0.01), and chlorpromazine (4 mg/kg) (P < 0.01) attenuated apomorphine-induced climbing behavior. The present results strongly support the involvement of NMDA glutamate receptors in the mode of action of psychollatine (1).]]></abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>16562831</pmid><doi>10.1021/np050291v</doi><tpages>4</tpages></addata></record> |
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| subjects | amphetamine Amphetamine - pharmacology Animals Antipsychotic Agents - chemistry Antipsychotic Agents - isolation & purification Antipsychotic Agents - pharmacology apomorphine Apomorphine - pharmacology Biological and medical sciences Brazil Chlorpromazine - pharmacology Diazepam - pharmacology Dizocilpine Maleate - pharmacology dopamine dopamine receptor General pharmacology glutamate receptor glutamic acid glycosides Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology indole alkaloids Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Indole Alkaloids - pharmacology Male Medical sciences Memory - drug effects Mice Models, Biological Molecular Structure monoterpenoids Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry psychollatine Psychopharmacology Psychotria Psychotria - chemistry Psychotria umbellata receptors Receptors, Dopamine - physiology Receptors, GABA-A - drug effects Receptors, N-Methyl-D-Aspartate - physiology Receptors, Serotonin - drug effects Rubiaceae seizures Serotonin Receptor Agonists - pharmacology signal transduction |
| title | Role of Glutamate and Dopamine Receptors in the Psychopharmacological Profile of the Indole Alkaloid Psychollatine |
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