Phenotypic changes of p53, HER2, and FAS system in multiple normal tissues surrounding breast cancer

To determine whether phenotypic field changes occur in tissues adjacent to carcinoma, we assayed, by immunohistochemistry, the expression of HER‐2, p53, Fas, and FasL in 72 breast cancers (BC) and multiple autologous peritumoral tissues (PTTs) sampled up to 5 cm distance and in 44 benign breast tumo...

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Veröffentlicht in:	Journal of cellular physiology 2005-07, Vol.204 (1), p.106-112
Hauptverfasser:	Mottolese, Marcella, Nádasi, Edit A., Botti, Claudio, Cianciulli, Anna M., Merola, Roberta, Buglioni, Simonetta, Benevolo, Maria, Giannarelli, Diana, Marandino, Ferdinando, Donnorso, Raffaele Perrone, Venturo, Irene, Natali, Pier Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - metabolism Breast - cytology Breast - metabolism Breast - pathology Breast Diseases - metabolism Breast Diseases - pathology Breast Neoplasms - metabolism Breast Neoplasms - pathology Early Diagnosis Fas Ligand Protein fas Receptor - metabolism Female Humans Immunohistochemistry Membrane Glycoproteins - metabolism Phenotype Receptor, ErbB-2 - metabolism Tumor Suppressor Protein p53 - metabolism
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