Successful use of recombinant factor VIIa for emergency fasciotomy in a patient with hemophilia A and high‐titer inhibitor unresponsive to factor VIII inhibitor bypassing activity

We report a patient with hemophilia A and high‐titer factor VIII inhibitor who developed compartment syndrome of his forearm following trauma. Emergency fasciotomy was performed. Initial hemostatic treatment with factor VIII inhibitor bypassing activity (FEIBA) was unsuccessful. Bleeding was control...

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Veröffentlicht in:	American journal of hematology 2005-05, Vol.79 (1), p.58-60
1. Verfasser:	Watts, Raymond G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoantibodies - blood Biological and medical sciences Child compartment syndrome Emergencies factor VIIa Factor VIIa - therapeutic use Factor VIII - antagonists & inhibitors Fasciotomy FEIBA Hematologic and hematopoietic diseases hemophilia A Hemophilia A - blood Hemophilia A - drug therapy Hemophilia A - immunology hemorrhage Humans inhibitor Male Medical sciences Platelet diseases and coagulopathies Recombinant Proteins - therapeutic use
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Zusammenfassung:	We report a patient with hemophilia A and high‐titer factor VIII inhibitor who developed compartment syndrome of his forearm following trauma. Emergency fasciotomy was performed. Initial hemostatic treatment with factor VIII inhibitor bypassing activity (FEIBA) was unsuccessful. Bleeding was controlled with recombinant factor VIIa. Am. J. Hematol. 79:58–60, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.20314