Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts

In skin, fibroblasts of the connective tissue play a decisive role in epidermal homeostasis and repair by contributing to the regulation of keratinocyte proliferation and differentiation. The AP-1 transcription factor subunit JUN plays a crucial role in this mesenchymal-epithelial interplay by regul...

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Veröffentlicht in:	Journal of cell science 2005-05, Vol.118 (9), p.1981-1989
Hauptverfasser:	Florin, Lore, Maas-Szabowski, Nicole, Werner, Sabine, Szabowski, Axel, Angel, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - biosynthesis Carrier Proteins - metabolism Cell Differentiation Cell Line Cell Proliferation Chemokine CXCL12 Chemokines, CXC - biosynthesis Chemokines, CXC - metabolism Coculture Techniques Cytokines - biosynthesis Cytokines - metabolism DNA, Complementary - metabolism Fibroblast Growth Factor 7 Fibroblast Growth Factors - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fluorescent Antibody Technique, Indirect Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Humans In Situ Hybridization Keratinocytes - cytology Keratinocytes - metabolism Mesoderm - metabolism Mice Microscopy, Phase-Contrast Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-jun - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism Skin - metabolism Time Factors Up-Regulation Wound Healing
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