HSP70 inhibits smac release from the mitochondria and protects against H2O2-induced apoptosis in C2C12 myogenic cells

To observe whether HSP70 could protect against H2O2-induced apoptosis in C2C12 myogenic cells by inhibiting Smac release from the mitochondria. HSP70 gene and full length Smac gene was transiently transfected in C2C12 myogenic cells by lipofectamine and the protein levels of HSP70 and Smac were anal...

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Veröffentlicht in:	Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2005-02, Vol.30 (1), p.32-37
Hauptverfasser:	Jiang, Bi-mei, Xiao, Wei-min, Shi, Yong-zhong, Liu, Mei-dong, Xiao, Xian-zhong
Format:	Artikel
Sprache:	chi
Schlagworte:	Apoptosis - drug effects Cells, Cultured HSP70 Heat-Shock Proteins - pharmacology Humans Hydrogen Peroxide Intracellular Signaling Peptides and Proteins - metabolism Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondrial Proteins - antagonists & inhibitors Mitochondrial Proteins - metabolism Myoblasts - metabolism Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism
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