Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors
Germ cell tumors (GCTs) are among the most common malignancies in young men. We have previously documented that patients with GCT frequently produce serum antibodies directed against proteins encoded by human endogenous retrovirus (HERV) type K sequences. Transcripts originating from the env gene of...
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| Veröffentlicht in: | Oncogene 2005-04, Vol.24 (19), p.3223-3228 |
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| creator | Galli, Uwe M Sauter, Marlies Lecher, Bernd Maurer, Simone Herbst, Hermann Roemer, Klaus Mueller-Lantzsch, Nikolaus |
| description | Germ cell tumors (GCTs) are among the most common malignancies in young men. We have previously documented that patients with GCT frequently produce serum antibodies directed against proteins encoded by human endogenous retrovirus (HERV) type K sequences. Transcripts originating from the
env
gene of HERV-K, including the
rec
-relative of human immunodeficiency virus
rev
, are highly expressed in GCTs. We report here that mice that inducibly express HERV-K
rec
show a disturbed germ cell development and may exhibit, by 19 months of age, changes reminiscent of carcinoma
in situ
, the predecessor lesion of classic seminoma in humans. This provides the first direct evidence that the expression of a human endogenous retroviral gene previously established as a marker in human germ cell tumors may contribute to organ-specific tumorigenesis in a transgenic mouse model. |
| doi_str_mv | 10.1038/sj.onc.1208543 |
| format | Article |
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env
gene of HERV-K, including the
rec
-relative of human immunodeficiency virus
rev
, are highly expressed in GCTs. We report here that mice that inducibly express HERV-K
rec
show a disturbed germ cell development and may exhibit, by 19 months of age, changes reminiscent of carcinoma
in situ
, the predecessor lesion of classic seminoma in humans. This provides the first direct evidence that the expression of a human endogenous retroviral gene previously established as a marker in human germ cell tumors may contribute to organ-specific tumorigenesis in a transgenic mouse model.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1208543</identifier><identifier>PMID: 15735668</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alternative Splicing ; Animals ; Antibodies ; Apoptosis ; Biological and medical sciences ; Blotting, Western ; Cancer ; Carcinoma in Situ - etiology ; Carcinoma in Situ - virology ; Cell Biology ; Cell Line, Tumor ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Cells ; Endogenous Retroviruses - genetics ; Env gene ; Env protein ; Fundamental and applied biological sciences. Psychology ; Genomes ; Germ Cells - cytology ; Germinoma - metabolism ; HIV ; Human endogenous retrovirus ; Human Genetics ; Human immunodeficiency virus ; Humans ; Infections ; Internal Medicine ; Leukemia ; Male ; Medicine ; Medicine & Public Health ; Mice ; Mice, Transgenic ; Microscopy, Fluorescence ; Models, Genetic ; Molecular and cellular biology ; Neoplasms, Germ Cell and Embryonal - metabolism ; Oncology ; Protein Structure, Tertiary ; Proteins ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Seminiferous Tubules - metabolism ; Seminoma ; short-report ; Time Factors ; Transgenic animals ; Transgenic mice ; Tumorigenesis ; Tumors ; Viral Envelope Proteins - metabolism ; Viral Envelope Proteins - physiology ; Virology ; Viruses</subject><ispartof>Oncogene, 2005-04, Vol.24 (19), p.3223-3228</ispartof><rights>Springer Nature Limited 2005</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 28, 2005</rights><rights>Nature Publishing Group 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-28ca0bf293b4c2d3b26bab618c4670e74a65906707b4330165e2ecfb01146f1e3</citedby><cites>FETCH-LOGICAL-c556t-28ca0bf293b4c2d3b26bab618c4670e74a65906707b4330165e2ecfb01146f1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.onc.1208543$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.onc.1208543$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16737592$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15735668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galli, Uwe M</creatorcontrib><creatorcontrib>Sauter, Marlies</creatorcontrib><creatorcontrib>Lecher, Bernd</creatorcontrib><creatorcontrib>Maurer, Simone</creatorcontrib><creatorcontrib>Herbst, Hermann</creatorcontrib><creatorcontrib>Roemer, Klaus</creatorcontrib><creatorcontrib>Mueller-Lantzsch, Nikolaus</creatorcontrib><title>Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Germ cell tumors (GCTs) are among the most common malignancies in young men. We have previously documented that patients with GCT frequently produce serum antibodies directed against proteins encoded by human endogenous retrovirus (HERV) type K sequences. Transcripts originating from the
env
gene of HERV-K, including the
rec
-relative of human immunodeficiency virus
rev
, are highly expressed in GCTs. We report here that mice that inducibly express HERV-K
rec
show a disturbed germ cell development and may exhibit, by 19 months of age, changes reminiscent of carcinoma
in situ
, the predecessor lesion of classic seminoma in humans. This provides the first direct evidence that the expression of a human endogenous retroviral gene previously established as a marker in human germ cell tumors may contribute to organ-specific tumorigenesis in a transgenic mouse model.</description><subject>Alternative Splicing</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Cancer</subject><subject>Carcinoma in Situ - etiology</subject><subject>Carcinoma in Situ - virology</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Cells</subject><subject>Endogenous Retroviruses - genetics</subject><subject>Env gene</subject><subject>Env protein</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genomes</subject><subject>Germ Cells - cytology</subject><subject>Germinoma - metabolism</subject><subject>HIV</subject><subject>Human endogenous retrovirus</subject><subject>Human Genetics</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Microscopy, Fluorescence</subject><subject>Models, Genetic</subject><subject>Molecular and cellular biology</subject><subject>Neoplasms, Germ Cell and Embryonal - metabolism</subject><subject>Oncology</subject><subject>Protein Structure, Tertiary</subject><subject>Proteins</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Seminiferous Tubules - metabolism</subject><subject>Seminoma</subject><subject>short-report</subject><subject>Time Factors</subject><subject>Transgenic animals</subject><subject>Transgenic mice</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>Viral Envelope Proteins - metabolism</subject><subject>Viral Envelope Proteins - physiology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkl1rFDEUhoModrt666UERa-cbb4zc1mKWqHgjV6HTObMNstMsiYzlf4U_63ZdnBFWiSQHJLnfOW8CL2iZEMJr8_ybhOD21BGain4E7SiQqtKykY8RSvSSFI1jLMTdJrzjhCiG8KeoxMqNZdK1Sv063IebcAQuriFEOeME0wp3vh0ZzrswwSphwQZ__TTNd5CGrGDYcAd3MAQ9yOEqVB49A6wDR0e7S12ds5Q9uR8iKM9vGc_zR_wdA14n6ADBznHhAfIPgYc-78CT_MYU36BnvV2yPByOdfo-6eP3y4uq6uvn79cnF9VTko1Vax2lrQ9a3grHOt4y1RrW0VrJ5QmoIVVsiHF1K3gnFAlgYHrW0KpUD0Fvkbv7-PuU_wxQ57M6POhDhug_IdRWje8Lp_9P5DqWgjZ6AK-_QfcxTmF0oRhSlDONa9Vod48SrEyHikK-ifU1g5gfOjjlKw75DXntG6IprKWhdo8QJXVQZlKDND7cv-Qg0sx5wS92Sc_2nRrKDEHXZm8M0VXZtFVcXi9FDu3I3RHfBFSAd4tgM3ODn2ywfl85JTmWhYprtHZPZfLUygzP3b9SOrfYF7lpA</recordid><startdate>20050428</startdate><enddate>20050428</enddate><creator>Galli, Uwe M</creator><creator>Sauter, Marlies</creator><creator>Lecher, Bernd</creator><creator>Maurer, Simone</creator><creator>Herbst, Hermann</creator><creator>Roemer, Klaus</creator><creator>Mueller-Lantzsch, Nikolaus</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050428</creationdate><title>Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors</title><author>Galli, Uwe M ; Sauter, Marlies ; Lecher, Bernd ; Maurer, Simone ; Herbst, Hermann ; Roemer, Klaus ; Mueller-Lantzsch, Nikolaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-28ca0bf293b4c2d3b26bab618c4670e74a65906707b4330165e2ecfb01146f1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Alternative Splicing</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Cancer</topic><topic>Carcinoma in Situ - etiology</topic><topic>Carcinoma in Situ - virology</topic><topic>Cell Biology</topic><topic>Cell Line, Tumor</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Cells</topic><topic>Endogenous Retroviruses - genetics</topic><topic>Env gene</topic><topic>Env protein</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genomes</topic><topic>Germ Cells - cytology</topic><topic>Germinoma - metabolism</topic><topic>HIV</topic><topic>Human endogenous retrovirus</topic><topic>Human Genetics</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Microscopy, Fluorescence</topic><topic>Models, Genetic</topic><topic>Molecular and cellular biology</topic><topic>Neoplasms, Germ Cell and Embryonal - metabolism</topic><topic>Oncology</topic><topic>Protein Structure, Tertiary</topic><topic>Proteins</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Seminiferous Tubules - metabolism</topic><topic>Seminoma</topic><topic>short-report</topic><topic>Time Factors</topic><topic>Transgenic animals</topic><topic>Transgenic mice</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>Viral Envelope Proteins - metabolism</topic><topic>Viral Envelope Proteins - physiology</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galli, Uwe M</creatorcontrib><creatorcontrib>Sauter, Marlies</creatorcontrib><creatorcontrib>Lecher, Bernd</creatorcontrib><creatorcontrib>Maurer, Simone</creatorcontrib><creatorcontrib>Herbst, Hermann</creatorcontrib><creatorcontrib>Roemer, Klaus</creatorcontrib><creatorcontrib>Mueller-Lantzsch, Nikolaus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galli, Uwe M</au><au>Sauter, Marlies</au><au>Lecher, Bernd</au><au>Maurer, Simone</au><au>Herbst, Hermann</au><au>Roemer, Klaus</au><au>Mueller-Lantzsch, Nikolaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2005-04-28</date><risdate>2005</risdate><volume>24</volume><issue>19</issue><spage>3223</spage><epage>3228</epage><pages>3223-3228</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>Germ cell tumors (GCTs) are among the most common malignancies in young men. We have previously documented that patients with GCT frequently produce serum antibodies directed against proteins encoded by human endogenous retrovirus (HERV) type K sequences. Transcripts originating from the
env
gene of HERV-K, including the
rec
-relative of human immunodeficiency virus
rev
, are highly expressed in GCTs. We report here that mice that inducibly express HERV-K
rec
show a disturbed germ cell development and may exhibit, by 19 months of age, changes reminiscent of carcinoma
in situ
, the predecessor lesion of classic seminoma in humans. This provides the first direct evidence that the expression of a human endogenous retroviral gene previously established as a marker in human germ cell tumors may contribute to organ-specific tumorigenesis in a transgenic mouse model.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15735668</pmid><doi>10.1038/sj.onc.1208543</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oncogene, 2005-04, Vol.24 (19), p.3223-3228 |
| issn | 0950-9232 1476-5594 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Alternative Splicing Animals Antibodies Apoptosis Biological and medical sciences Blotting, Western Cancer Carcinoma in Situ - etiology Carcinoma in Situ - virology Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells Endogenous Retroviruses - genetics Env gene Env protein Fundamental and applied biological sciences. Psychology Genomes Germ Cells - cytology Germinoma - metabolism HIV Human endogenous retrovirus Human Genetics Human immunodeficiency virus Humans Infections Internal Medicine Leukemia Male Medicine Medicine & Public Health Mice Mice, Transgenic Microscopy, Fluorescence Models, Genetic Molecular and cellular biology Neoplasms, Germ Cell and Embryonal - metabolism Oncology Protein Structure, Tertiary Proteins Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Seminiferous Tubules - metabolism Seminoma short-report Time Factors Transgenic animals Transgenic mice Tumorigenesis Tumors Viral Envelope Proteins - metabolism Viral Envelope Proteins - physiology Virology Viruses |
| title | Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors |
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