Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer

Background: Gefitinib is a selective inhibitor of the epidermal growth factor (EGFR) tyrosine kinase, which is overexpressed in many cancers, including non–small-cell lung cancer (NSCLC). We carried out a clinical study to compare the relationship between EGFR gene copy number, EGFR protein expressi...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2005-05, Vol.97 (9), p.643-655
Hauptverfasser:	Cappuzzo, Federico, Hirsch, Fred R., Rossi, Elisa, Bartolini, Stefania, Ceresoli, Giovanni L., Bemis, Lynne, Haney, Jerry, Witta, Samir, Danenberg, Kathleen, Domenichini, Irene, Ludovini, Vienna, Magrini, Elisabetta, Gregorc, Vanesa, Doglioni, Claudio, Sidoni, Angelo, Tonato, Maurizio, Franklin, Wilbur A., Crino, Lucio, Bunn, Paul A., Varella-Garcia, Marileila
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Chemotherapy Clinical trials Disease-Free Survival Female Gene expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Immunohistochemistry In Situ Hybridization, Fluorescence Inhibitor drugs Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Male Medical sciences Middle Aged Multivariate Analysis Pharmacology. Drug treatments Predictive Value of Tests Proportional Hazards Models Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - drug effects Protein-Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins - drug effects Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Research Design Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Survival Analysis Tumors
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