Evidence for covalent lipoyl adduction with dopaquinone following tyrosinase-catalyzed oxidation

Previous studies have examined the conjugation of sulfhydryl compounds such as l-cysteine and glutathione with DOPA-quinone following the oxidation of tyrosine and DOPA by tyrosinase. These covalent reactions play a key role in the regulation and metabolism of pigment cells. We report on the first d...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-04, Vol.343 (1), p.15-20
Hauptverfasser:	Tsuji-Naito, Kentaro, Hatani, Tomoko, Okada, Takeshi, Tehara, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoquinones - chemistry Benzoquinones - metabolism Catalysis Chromatography, High Pressure Liquid Dihydrolipoic acid Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - analysis Dihydroxyphenylalanine - chemistry Dihydroxyphenylalanine - metabolism DOPA Melanin Monophenol Monooxygenase - chemistry Monophenol Monooxygenase - metabolism Oxidation-Reduction Quinone Thioctic Acid - analogs & derivatives Thioctic Acid - analysis Thioctic Acid - chemistry Thiol Tyrosinase
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