In Vivo Regulation of Grp78/BiP Transcription in the Embryonic Heart: ROLE OF THE ENDOPLASMIC RETICULUM STRESS RESPONSE ELEMENT AND GATA-4

The transcriptional activation of GRP78, which controls multiple signaling pathways of the unfolded protein response, has been used extensively as an indicator for the onset of endoplasmic reticulum stress in tissue culture systems. Here we investigate the mechanism of Grp78 induction during mouse e...

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Veröffentlicht in:	The Journal of biological chemistry 2006-03, Vol.281 (13), p.8877-8887
Hauptverfasser:	Mao, Changhui, Tai, Wei-Cheng, Bai, Yan, Poizat, Coralie, Lee, Amy S
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - genetics Animals beta-Galactosidase - metabolism Cell Culture Techniques Cell Line Cells, Cultured Chromatin Immunoprecipitation Embryo, Mammalian Endoplasmic Reticulum - metabolism Enzyme Inhibitors - pharmacology Female GATA4 Transcription Factor - genetics GATA4 Transcription Factor - metabolism Gene Expression Regulation, Developmental Genes, Reporter Heat-Shock Proteins - genetics HeLa Cells Humans Luciferases - metabolism Mice Mice, Transgenic Molecular Chaperones - genetics Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Pregnancy Promoter Regions, Genetic Rats Response Elements - genetics Thapsigargin - pharmacology Transcription, Genetic Transfection Tunicamycin - pharmacology
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