Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells

Human embryonic stem cells (hESCs) are routinely cultured on fibroblast feeder layers or in fibroblast-conditioned medium (CM). Bone morphogenetic proteins (BMPs) have previously been shown to induce hESC differentiation, in apparent contrast to mouse embryonic stem (ES) cells, in which BMP4 synergi...

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Veröffentlicht in:	Nature methods 2005-03, Vol.2 (3), p.185-190
Hauptverfasser:	Xu, Ren-He, Peck, Ruthann M, Li, Dong S, Feng, Xuezhu, Ludwig, Tenneille, Thomson, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Bone Morphogenetic Proteins - administration & dosage Bone Morphogenetic Proteins - metabolism Carrier Proteins Cell Culture Techniques - methods Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line Cell proliferation Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Combinations Fibroblast Growth Factor 2 - administration & dosage Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Humans Leukemia Life Sciences Physiological aspects Proteomics Signal Transduction - drug effects Signal Transduction - physiology Stem cell research Stem cells Stem Cells - cytology Stem Cells - drug effects Stem Cells - physiology Tissue Engineering - methods
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