Relationship of quality of life and physical function measures with disease activity in children with systemic lupus erythematosus
The objective of this study is to assess relationship of systemic lupus erythematosus (SLE) activity with quality of life (QOL) and physical function and determine which is more closely correlated with SLE activity in children; and identify factors critical to children’s QOL. In this cross-sectional...
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Veröffentlicht in: | Lupus 2005-01, Vol.14 (4), p.280-287 |
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description | The objective of this study is to assess relationship of systemic lupus erythematosus (SLE) activity with quality of life (QOL) and physical function and determine which is more closely correlated with SLE activity in children; and identify factors critical to children’s QOL. In this cross-sectional study, children with SLE and parents completed corresponding versions of physical function (Childhood Health Assessment Questionnaire -CHAQ), and QOL (Pediatric Quality of Life Inventory -PedsQL Generic/Rheumatology modules) questionnaires. SLE Disease Activity Index (SLEDAI), Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI), severity, self-concept and socioeconomic status (SES) were measured. For 24 children, CHAQ scores significantly correlated with SLEDAI (rho = 0.4, p = 0.04), SDI (rho = 0.6, p = 0.004), and associated with severity (p = 0.03). PedsQL scores did not significantly correlate with above parameters. Higher self-concept/SES correlated (p, 0.05) with better physical function and QOL. For 19 parents, the only significant correlation was between SLEDAI and Worry domain - Rheumatology module (rho = 0.5, p = 0.01). Lack of strong correlation of disease activity with QOL and physical function suggests that they are different constructs with partial overlap, and should be considered collectively while evaluating the impact of SLE on children/families. Self-concept and SES should be assessed while measuring QOL in children. Larger sample is required to confirm results. |
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In this cross-sectional study, children with SLE and parents completed corresponding versions of physical function (Childhood Health Assessment Questionnaire -CHAQ), and QOL (Pediatric Quality of Life Inventory -PedsQL Generic/Rheumatology modules) questionnaires. SLE Disease Activity Index (SLEDAI), Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI), severity, self-concept and socioeconomic status (SES) were measured. For 24 children, CHAQ scores significantly correlated with SLEDAI (rho = 0.4, p = 0.04), SDI (rho = 0.6, p = 0.004), and associated with severity (p = 0.03). PedsQL scores did not significantly correlate with above parameters. Higher self-concept/SES correlated (p, 0.05) with better physical function and QOL. For 19 parents, the only significant correlation was between SLEDAI and Worry domain - Rheumatology module (rho = 0.5, p = 0.01). Lack of strong correlation of disease activity with QOL and physical function suggests that they are different constructs with partial overlap, and should be considered collectively while evaluating the impact of SLE on children/families. Self-concept and SES should be assessed while measuring QOL in children. Larger sample is required to confirm results.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1191/0961203305lu2075oa</identifier><identifier>PMID: 15864914</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adolescent ; Child ; Cross-Sectional Studies ; Female ; Humans ; Lupus Erythematosus, Systemic - physiopathology ; Lupus Erythematosus, Systemic - psychology ; Male ; Parents ; Psychology ; Quality of Life ; Self Concept ; Socioeconomic Factors ; Surveys and Questionnaires</subject><ispartof>Lupus, 2005-01, Vol.14 (4), p.280-287</ispartof><rights>2005 Arnold</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-37b7bba9ae077499f2edae9c2893d895005f546ff47b0367e119a1a585dca4e73</citedby><cites>FETCH-LOGICAL-c399t-37b7bba9ae077499f2edae9c2893d895005f546ff47b0367e119a1a585dca4e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1191/0961203305lu2075oa$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1191/0961203305lu2075oa$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15864914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moorthy, L N</creatorcontrib><creatorcontrib>Harrison, M J</creatorcontrib><creatorcontrib>Peterson, M</creatorcontrib><creatorcontrib>Onel, K B</creatorcontrib><creatorcontrib>Lehman, T JA</creatorcontrib><title>Relationship of quality of life and physical function measures with disease activity in children with systemic lupus erythematosus</title><title>Lupus</title><addtitle>Lupus</addtitle><description>The objective of this study is to assess relationship of systemic lupus erythematosus (SLE) activity with quality of life (QOL) and physical function and determine which is more closely correlated with SLE activity in children; and identify factors critical to children’s QOL. In this cross-sectional study, children with SLE and parents completed corresponding versions of physical function (Childhood Health Assessment Questionnaire -CHAQ), and QOL (Pediatric Quality of Life Inventory -PedsQL Generic/Rheumatology modules) questionnaires. SLE Disease Activity Index (SLEDAI), Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI), severity, self-concept and socioeconomic status (SES) were measured. For 24 children, CHAQ scores significantly correlated with SLEDAI (rho = 0.4, p = 0.04), SDI (rho = 0.6, p = 0.004), and associated with severity (p = 0.03). PedsQL scores did not significantly correlate with above parameters. Higher self-concept/SES correlated (p, 0.05) with better physical function and QOL. For 19 parents, the only significant correlation was between SLEDAI and Worry domain - Rheumatology module (rho = 0.5, p = 0.01). Lack of strong correlation of disease activity with QOL and physical function suggests that they are different constructs with partial overlap, and should be considered collectively while evaluating the impact of SLE on children/families. Self-concept and SES should be assessed while measuring QOL in children. Larger sample is required to confirm results.</description><subject>Adolescent</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - physiopathology</subject><subject>Lupus Erythematosus, Systemic - psychology</subject><subject>Male</subject><subject>Parents</subject><subject>Psychology</subject><subject>Quality of Life</subject><subject>Self Concept</subject><subject>Socioeconomic Factors</subject><subject>Surveys and Questionnaires</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0UtrFTEUB_AgFnutfgEXEly4G5vHZDJZSqkPKBRKXQ-ZzImTknl0zkSZrZ_cDPdCQUFXSTi_8w_JIeQNZx84N_ySmYoLJiVTMQmm1WSfkQMvtS5yRTwnhx0UuzgnLxEfGGOSm-oFOeeqrkrDywP5dQfRrmEasQ8znTx9TDaGddu3MXigduzo3G8YnI3Up9HtmA5gMS2A9GdYe9oFzOdsc_HH3hxG6voQuwXGo8ANVxiCozHNCSks29rDYNcJE74iZ95GhNen9YJ8-3R9f_WluLn9_PXq403hpDFrIXWr29YaC0zr0hgvoLNgnKiN7GqjGFNelZX3pW6ZrDTkP7Lcqlp1zpag5QV5f8ydl-kxAa7NENBBjHaEKWFTaW1Yrfl_Ide1rKVWGb77Az5MaRnzIxohRCU5U3VG4ojcMiEu4Jt5CYNdtoazZp9j8_ccc9PbU3JqB-ieWk6Dy-DyCNB-h6dr_xH5G7SnqmA</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Moorthy, L N</creator><creator>Harrison, M J</creator><creator>Peterson, M</creator><creator>Onel, K B</creator><creator>Lehman, T JA</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>Relationship of quality of life and physical function measures with disease activity in children with systemic lupus erythematosus</title><author>Moorthy, L N ; Harrison, M J ; Peterson, M ; Onel, K B ; Lehman, T JA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-37b7bba9ae077499f2edae9c2893d895005f546ff47b0367e119a1a585dca4e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - physiopathology</topic><topic>Lupus Erythematosus, Systemic - psychology</topic><topic>Male</topic><topic>Parents</topic><topic>Psychology</topic><topic>Quality of Life</topic><topic>Self Concept</topic><topic>Socioeconomic Factors</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moorthy, L N</creatorcontrib><creatorcontrib>Harrison, M J</creatorcontrib><creatorcontrib>Peterson, M</creatorcontrib><creatorcontrib>Onel, K B</creatorcontrib><creatorcontrib>Lehman, T JA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moorthy, L N</au><au>Harrison, M J</au><au>Peterson, M</au><au>Onel, K B</au><au>Lehman, T JA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of quality of life and physical function measures with disease activity in children with systemic lupus erythematosus</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>14</volume><issue>4</issue><spage>280</spage><epage>287</epage><pages>280-287</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>The objective of this study is to assess relationship of systemic lupus erythematosus (SLE) activity with quality of life (QOL) and physical function and determine which is more closely correlated with SLE activity in children; and identify factors critical to children’s QOL. In this cross-sectional study, children with SLE and parents completed corresponding versions of physical function (Childhood Health Assessment Questionnaire -CHAQ), and QOL (Pediatric Quality of Life Inventory -PedsQL Generic/Rheumatology modules) questionnaires. SLE Disease Activity Index (SLEDAI), Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI), severity, self-concept and socioeconomic status (SES) were measured. For 24 children, CHAQ scores significantly correlated with SLEDAI (rho = 0.4, p = 0.04), SDI (rho = 0.6, p = 0.004), and associated with severity (p = 0.03). PedsQL scores did not significantly correlate with above parameters. Higher self-concept/SES correlated (p, 0.05) with better physical function and QOL. For 19 parents, the only significant correlation was between SLEDAI and Worry domain - Rheumatology module (rho = 0.5, p = 0.01). Lack of strong correlation of disease activity with QOL and physical function suggests that they are different constructs with partial overlap, and should be considered collectively while evaluating the impact of SLE on children/families. Self-concept and SES should be assessed while measuring QOL in children. Larger sample is required to confirm results.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>15864914</pmid><doi>10.1191/0961203305lu2075oa</doi><tpages>8</tpages></addata></record> |
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subjects | Adolescent Child Cross-Sectional Studies Female Humans Lupus Erythematosus, Systemic - physiopathology Lupus Erythematosus, Systemic - psychology Male Parents Psychology Quality of Life Self Concept Socioeconomic Factors Surveys and Questionnaires |
title | Relationship of quality of life and physical function measures with disease activity in children with systemic lupus erythematosus |
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