A study of the pharmacokinetics and safety of recombinant activated factor VII in healthy Caucasian and Japanese subjects

In this randomized, placebo-controlled, double-blind, single-centre, dose escalation study, we report the first evaluation of the pharmacokinetics and safety of recombinant activated factor VII (rFVIIa) in healthy Caucasian and Japanese subjects. Thirty-two healthy subjects were stratified according...

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Veröffentlicht in:	Blood coagulation & fibrinolysis 2005-06, Vol.16 (4), p.259-266
Hauptverfasser:	Fridberg, Marianne J, Hedner, Ulla, Roberts, Harold R, Erhardtsen, Elisabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Area Under Curve Asian Continental Ancestry Group Biological and medical sciences Blood coagulation. Blood cells Dose-Response Relationship, Drug Double-Blind Method European Continental Ancestry Group Factor VII - adverse effects Factor VII - pharmacokinetics Factor VIIa Female Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Humans Male Medical sciences Middle Aged Molecular and cellular biology Pharmacokinetics Platelet diseases and coagulopathies Recombinant Proteins - adverse effects Recombinant Proteins - blood Recombinant Proteins - pharmacokinetics
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