Reduced nNOS expression induced by repeated nicotine treatment in μ-opioid receptor knockout mice

To determine whether neuronal nitric oxide synthase (nNOS) is involved in nicotine-induced behavioral sensitization in μ-opioid receptor knockout mice we adopted an immunohistochemical approach. Our results confirm that repeated nicotine administration increased locomotor activity in wild-type mice,...

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Veröffentlicht in:	Neuroscience letters 2005-05, Vol.380 (1), p.70-74
Hauptverfasser:	Yoo, Ji-Hoon, Cho, Jae-Han, Lee, Seok-Yong, Loh, Horace H., Ho, Ing K., Jang, Choon-Gon
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Brain - drug effects Brain - metabolism Cell Culture Techniques - methods Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Immunohistochemistry Immunohistochemistry - methods Knockout mice Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nicotine Nicotine - administration & dosage Nicotinic Agonists - administration & dosage Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I Nnos Receptors, Opioid, mu - deficiency Sensitization Time Factors Vertebrates: nervous system and sense organs μ-Opioid receptors
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