Reduced nNOS expression induced by repeated nicotine treatment in μ-opioid receptor knockout mice
To determine whether neuronal nitric oxide synthase (nNOS) is involved in nicotine-induced behavioral sensitization in μ-opioid receptor knockout mice we adopted an immunohistochemical approach. Our results confirm that repeated nicotine administration increased locomotor activity in wild-type mice,...
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| Veröffentlicht in: | Neuroscience letters 2005-05, Vol.380 (1), p.70-74 |
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| container_title | Neuroscience letters |
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| creator | Yoo, Ji-Hoon Cho, Jae-Han Lee, Seok-Yong Loh, Horace H. Ho, Ing K. Jang, Choon-Gon |
| description | To determine whether neuronal nitric oxide synthase (nNOS) is involved in nicotine-induced behavioral sensitization in μ-opioid receptor knockout mice we adopted an immunohistochemical approach. Our results confirm that repeated nicotine administration increased locomotor activity in wild-type mice, but failed to increase locomotor activity in μ-opioid receptor knockout mice, thus suggesting that the μ-opioid receptor is involved in behavioral sensitization. Higher numbers of nNOS-positive cells were observed in the striatum of wild-type mice repeatedly treated with nicotine than in saline-treated wild-type mice. However, μ-opioid receptor knockout mice showed significantly lower nicotine-induced nNOS expression in the striatum versus wild-type mice. No differences were found in the hilus of the dentate gyrus between wild-type and μ-opioid receptor knockout mice. These findings demonstrate that the absence of μ-opioid receptors can cause a significant reduction in the expression of nNOS in the striatum, as induced by repeated nicotine treatment. |
| doi_str_mv | 10.1016/j.neulet.2005.01.001 |
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Our results confirm that repeated nicotine administration increased locomotor activity in wild-type mice, but failed to increase locomotor activity in μ-opioid receptor knockout mice, thus suggesting that the μ-opioid receptor is involved in behavioral sensitization. Higher numbers of nNOS-positive cells were observed in the striatum of wild-type mice repeatedly treated with nicotine than in saline-treated wild-type mice. However, μ-opioid receptor knockout mice showed significantly lower nicotine-induced nNOS expression in the striatum versus wild-type mice. No differences were found in the hilus of the dentate gyrus between wild-type and μ-opioid receptor knockout mice. These findings demonstrate that the absence of μ-opioid receptors can cause a significant reduction in the expression of nNOS in the striatum, as induced by repeated nicotine treatment.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2005.01.001</identifier><identifier>PMID: 15854753</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Analysis of Variance ; Animals ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Cell Culture Techniques - methods ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - drug effects ; Immunohistochemistry ; Immunohistochemistry - methods ; Knockout mice ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Nicotine ; Nicotine - administration & dosage ; Nicotinic Agonists - administration & dosage ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase - metabolism ; Nitric Oxide Synthase Type I ; Nnos ; Receptors, Opioid, mu - deficiency ; Sensitization ; Time Factors ; Vertebrates: nervous system and sense organs ; μ-Opioid receptors</subject><ispartof>Neuroscience letters, 2005-05, Vol.380 (1), p.70-74</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-400c45880ee3a50b5f62eb3c26b742affc41ffad5df726adfdd4760a7b4272d93</citedby><cites>FETCH-LOGICAL-c390t-400c45880ee3a50b5f62eb3c26b742affc41ffad5df726adfdd4760a7b4272d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394005000169$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16742982$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15854753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoo, Ji-Hoon</creatorcontrib><creatorcontrib>Cho, Jae-Han</creatorcontrib><creatorcontrib>Lee, Seok-Yong</creatorcontrib><creatorcontrib>Loh, Horace H.</creatorcontrib><creatorcontrib>Ho, Ing K.</creatorcontrib><creatorcontrib>Jang, Choon-Gon</creatorcontrib><title>Reduced nNOS expression induced by repeated nicotine treatment in μ-opioid receptor knockout mice</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>To determine whether neuronal nitric oxide synthase (nNOS) is involved in nicotine-induced behavioral sensitization in μ-opioid receptor knockout mice we adopted an immunohistochemical approach. Our results confirm that repeated nicotine administration increased locomotor activity in wild-type mice, but failed to increase locomotor activity in μ-opioid receptor knockout mice, thus suggesting that the μ-opioid receptor is involved in behavioral sensitization. Higher numbers of nNOS-positive cells were observed in the striatum of wild-type mice repeatedly treated with nicotine than in saline-treated wild-type mice. However, μ-opioid receptor knockout mice showed significantly lower nicotine-induced nNOS expression in the striatum versus wild-type mice. No differences were found in the hilus of the dentate gyrus between wild-type and μ-opioid receptor knockout mice. These findings demonstrate that the absence of μ-opioid receptors can cause a significant reduction in the expression of nNOS in the striatum, as induced by repeated nicotine treatment.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cell Culture Techniques - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Immunohistochemistry</subject><subject>Immunohistochemistry - methods</subject><subject>Knockout mice</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nicotine</subject><subject>Nicotine - administration & dosage</subject><subject>Nicotinic Agonists - administration & dosage</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase Type I</subject><subject>Nnos</subject><subject>Receptors, Opioid, mu - deficiency</subject><subject>Sensitization</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>μ-Opioid receptors</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M2K1TAUwPEginMdfQORbnTXepKmTbsRZPALBgf8WIc0OYHcaZOapIPzbj6Dz2QuvTA7V4HwO4fkT8hLCg0F2r89Nh63GXPDALoGaANAH5EDHQSrxSjYY3KAFnjdjhwuyLOUjlAg7fhTckG7oeOiaw9k-oZm02gq__Xme4W_14gpueAr5_f76b6KuKLKJ-N0yM5jlWO5WNDnwqq_f-qwuuBMgRrXHGJ164O-DVuuFqfxOXli1Zzwxfm8JD8_fvhx9bm-vvn05er9da3bEXLNATTvhgEQW9XB1Nme4dRq1k-CM2Wt5tRaZTpjBeuVscZw0YMSE2eCmbG9JG_2vWsMvzZMWS4uaZxn5TFsSfZCDEM_niDfoY4hpYhWrtEtKt5LCvLUVh7l3lae2kqgsrQtY6_O-7dpQfMwdI5ZwOszUEmr2UbltUsPri__GAdW3LvdYalx5zDKpB36UtuVglma4P7_kn_X8JwY</recordid><startdate>20050520</startdate><enddate>20050520</enddate><creator>Yoo, Ji-Hoon</creator><creator>Cho, Jae-Han</creator><creator>Lee, Seok-Yong</creator><creator>Loh, Horace H.</creator><creator>Ho, Ing K.</creator><creator>Jang, Choon-Gon</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050520</creationdate><title>Reduced nNOS expression induced by repeated nicotine treatment in μ-opioid receptor knockout mice</title><author>Yoo, Ji-Hoon ; Cho, Jae-Han ; Lee, Seok-Yong ; Loh, Horace H. ; Ho, Ing K. ; Jang, Choon-Gon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-400c45880ee3a50b5f62eb3c26b742affc41ffad5df726adfdd4760a7b4272d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cell Culture Techniques - methods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Immunohistochemistry</topic><topic>Immunohistochemistry - methods</topic><topic>Knockout mice</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Nicotine</topic><topic>Nicotine - administration & dosage</topic><topic>Nicotinic Agonists - administration & dosage</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase Type I</topic><topic>Nnos</topic><topic>Receptors, Opioid, mu - deficiency</topic><topic>Sensitization</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>μ-Opioid receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoo, Ji-Hoon</creatorcontrib><creatorcontrib>Cho, Jae-Han</creatorcontrib><creatorcontrib>Lee, Seok-Yong</creatorcontrib><creatorcontrib>Loh, Horace H.</creatorcontrib><creatorcontrib>Ho, Ing K.</creatorcontrib><creatorcontrib>Jang, Choon-Gon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoo, Ji-Hoon</au><au>Cho, Jae-Han</au><au>Lee, Seok-Yong</au><au>Loh, Horace H.</au><au>Ho, Ing K.</au><au>Jang, Choon-Gon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced nNOS expression induced by repeated nicotine treatment in μ-opioid receptor knockout mice</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2005-05-20</date><risdate>2005</risdate><volume>380</volume><issue>1</issue><spage>70</spage><epage>74</epage><pages>70-74</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>To determine whether neuronal nitric oxide synthase (nNOS) is involved in nicotine-induced behavioral sensitization in μ-opioid receptor knockout mice we adopted an immunohistochemical approach. Our results confirm that repeated nicotine administration increased locomotor activity in wild-type mice, but failed to increase locomotor activity in μ-opioid receptor knockout mice, thus suggesting that the μ-opioid receptor is involved in behavioral sensitization. Higher numbers of nNOS-positive cells were observed in the striatum of wild-type mice repeatedly treated with nicotine than in saline-treated wild-type mice. However, μ-opioid receptor knockout mice showed significantly lower nicotine-induced nNOS expression in the striatum versus wild-type mice. No differences were found in the hilus of the dentate gyrus between wild-type and μ-opioid receptor knockout mice. These findings demonstrate that the absence of μ-opioid receptors can cause a significant reduction in the expression of nNOS in the striatum, as induced by repeated nicotine treatment.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15854753</pmid><doi>10.1016/j.neulet.2005.01.001</doi><tpages>5</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Brain - drug effects Brain - metabolism Cell Culture Techniques - methods Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Immunohistochemistry Immunohistochemistry - methods Knockout mice Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nicotine Nicotine - administration & dosage Nicotinic Agonists - administration & dosage Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I Nnos Receptors, Opioid, mu - deficiency Sensitization Time Factors Vertebrates: nervous system and sense organs μ-Opioid receptors |
| title | Reduced nNOS expression induced by repeated nicotine treatment in μ-opioid receptor knockout mice |
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