Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat

Background and Aim: Olmesartan (RNH‐6270) is a newly developed anigotensin II receptor antagonist, and has been reported to be excreted into feces. To examine the mechanism of the biliary excretion of olmesartan, we studied its biliary excretion in rats. Methods: The biliary excretion of olmesarta...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2005-05, Vol.20 (5), p.784-788
Hauptverfasser:	TAKAYANAGI, MOTOE, SANO, NAOYO, TAKIKAWA, HAJIME
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - pharmacokinetics Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents ATP-Binding Cassette Transporters - physiology bile acids Biological and medical sciences Cephalosporins - pharmacology Common Bile Duct - drug effects Common Bile Duct - metabolism Eisai hyperbilirubinemic rats (EHBR) Gastroenterology. Liver. Pancreas. Abdomen Imidazoles - pharmacokinetics Male Medical sciences multidrug resistance protein 2 olmesartan (RNH-6270) Olmesartan Medoxomil P-glycoprotein Pharmacology. Drug treatments Phenothiazines - pharmacology Pravastatin - pharmacology Rats Rats, Mutant Strains Rats, Sprague-Dawley Sulfobromophthalein - pharmacology Taurochenodeoxycholic Acid - pharmacology Taurocholic Acid - pharmacology Tetrazoles - pharmacokinetics Vinblastine - pharmacology
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