Calpain inhibition and insulin action in cultured human muscle cells

Variation in the calpain 10 gene has been reported to increase susceptibility to type 2 diabetes. Part of this susceptibility appears to be mediated by a decrease in whole body insulin sensitivity. As skeletal muscle is the primary tissue site of the peripheral insulin resistance in type 2 diabetes,...

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Veröffentlicht in:	Molecular genetics and metabolism 2005-05, Vol.85 (1), p.54-60
Hauptverfasser:	Logie, L.J., Brown, A.E., Yeaman, S.J., Walker, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological Transport Calpain Calpain - antagonists & inhibitors Calpain - genetics Cell Culture Techniques Cells, Cultured Diabetes Mellitus, Type 2 - genetics DNA Primers Gene Expression Regulation, Enzymologic Genetic Predisposition to Disease Genotypes Glucose - metabolism Glucose transport Glycogen - biosynthesis Humans Insulin - pharmacology Insulin resistance Insulin Resistance - genetics Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Transcription, Genetic Type 2 diabetes
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