Vascular Endothelial Growth Factor-C Expression and Invasive Phenotype in Ovarian Carcinomas
Purpose: To investigate the biological correlation between vascular endothelial growth factor (VEGF)-C expression and invasive phenotype in ovarian carcinomas. Experimental Design: Gene and protein expression levels of VEGF-C in 10 ovarian carcinoma cell lines were correlated with invasive activity...
Gespeichert in:
| Veröffentlicht in: | Clinical cancer research 2005-05, Vol.11 (9), p.3225-3232 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3232 |
|---|---|
| container_issue | 9 |
| container_start_page | 3225 |
| container_title | Clinical cancer research |
| container_volume | 11 |
| creator | UEDA, Masatsugu HUNG, Yao-Ching TERAI, Yoshito KANDA, Koji KANEMURA, Masanori FUTAKUCHI, Hikari YAMAGUCHI, Hiroyuki AKISE, Daisuke YASUDA, Masayuki UEKI, Minoru |
| description | Purpose: To investigate the biological correlation between vascular endothelial growth factor (VEGF)-C expression and invasive phenotype
in ovarian carcinomas.
Experimental Design: Gene and protein expression levels of VEGF-C in 10 ovarian carcinoma cell lines were correlated with invasive activity of
the cells. The correlation between immunohistochemical expression of VEGF-C and tumor aggressiveness in 73 ovarian carcinomas
was also examined with respect to clinicopathologic features and patient outcome.
Results: VEGF-C gene and protein expression differed remarkably among the cell lines, and there was a statistical correlation among VEGF-C
expression, in vitro invasive activity, and matrix metalloproteinase-2 ( MMP-2 ) gene expression and its activity. Anti-VEGF-C and anti-MMP-2 antibodies inhibited the invasive activity of tumor cells.
VEGF-C expression in clinical tissue samples was well correlated with clinical stages, retroperitoneal lymph node metastasis,
MMP-2 expression, angiogenesis, lymphangiogenesis, and low apoptotic index (AI). The patients whose tumors had strong VEGF-C
expression and low AI underwent a poorer prognosis than did those with weak VEGF-C expression and high AI.
Conclusion: VEGF-C expression is closely related to invasive phenotype and affects the patient's survival in ovarian carcinomas. |
| doi_str_mv | 10.1158/1078-0432.CCR-04-1148 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67787144</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67787144</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-1e3e99b5543c801223f153ec13d836173b788adcf64f91566c2b7846f0764b3e3</originalsourceid><addsrcrecordid>eNqFkV1rFDEUhgdRbK3-BCU3ijdTc_I9lzJsa6FQEfVKCNnMGScym6zJ7Nb-e7PsSi-9ykt4znnhOU3zGuglgDQfgGrTUsHZZd9_qaEFEOZJcw5S6pYzJZ_W_I85a16U8otSEEDF8-asLlCagT5vfnx3xe9ml8kqDmmZcA5uJtc53S8TuXJ-SbntyerPNmMpIUXi4kBu4t6VsEfyecKYloctkhDJ3d7l4CLpXfYhpo0rL5tno5sLvjq9F823q9XX_lN7e3d903-8bb0EsbSAHLtuLaXg3lBgjI8gOXrgg-EKNF9rY9zgRyXGDqRSntUfoUaqlVhz5BfNu-PebU6_d1gWuwnF4zy7iGlXrNLaaBDiv2DtEpIBraA8gj6nUjKOdpvDxuUHC9Qe_NuDW3twa6v_GuzBf517cyrYrTc4PE6dhFfg7Qmo3t08Zhd9KI-c0txQ0VXu_ZGbws_pPmS0vpKY6xmw-p1qne0sZ0zyv7Aomvc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17345210</pqid></control><display><type>article</type><title>Vascular Endothelial Growth Factor-C Expression and Invasive Phenotype in Ovarian Carcinomas</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>UEDA, Masatsugu ; HUNG, Yao-Ching ; TERAI, Yoshito ; KANDA, Koji ; KANEMURA, Masanori ; FUTAKUCHI, Hikari ; YAMAGUCHI, Hiroyuki ; AKISE, Daisuke ; YASUDA, Masayuki ; UEKI, Minoru</creator><creatorcontrib>UEDA, Masatsugu ; HUNG, Yao-Ching ; TERAI, Yoshito ; KANDA, Koji ; KANEMURA, Masanori ; FUTAKUCHI, Hikari ; YAMAGUCHI, Hiroyuki ; AKISE, Daisuke ; YASUDA, Masayuki ; UEKI, Minoru</creatorcontrib><description>Purpose: To investigate the biological correlation between vascular endothelial growth factor (VEGF)-C expression and invasive phenotype
in ovarian carcinomas.
Experimental Design: Gene and protein expression levels of VEGF-C in 10 ovarian carcinoma cell lines were correlated with invasive activity of
the cells. The correlation between immunohistochemical expression of VEGF-C and tumor aggressiveness in 73 ovarian carcinomas
was also examined with respect to clinicopathologic features and patient outcome.
Results: VEGF-C gene and protein expression differed remarkably among the cell lines, and there was a statistical correlation among VEGF-C
expression, in vitro invasive activity, and matrix metalloproteinase-2 ( MMP-2 ) gene expression and its activity. Anti-VEGF-C and anti-MMP-2 antibodies inhibited the invasive activity of tumor cells.
VEGF-C expression in clinical tissue samples was well correlated with clinical stages, retroperitoneal lymph node metastasis,
MMP-2 expression, angiogenesis, lymphangiogenesis, and low apoptotic index (AI). The patients whose tumors had strong VEGF-C
expression and low AI underwent a poorer prognosis than did those with weak VEGF-C expression and high AI.
Conclusion: VEGF-C expression is closely related to invasive phenotype and affects the patient's survival in ovarian carcinomas.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-04-1148</identifier><identifier>PMID: 15867217</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Angiogenesis ; Antibodies - pharmacology ; Antigens, CD34 - analysis ; Antineoplastic agents ; Apoptosis ; Biological and medical sciences ; Cell Line, Tumor ; Cell Movement - drug effects ; Dose-Response Relationship, Drug ; Female ; Female genital diseases ; Gene Expression Regulation, Neoplastic ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; In Situ Nick-End Labeling ; Matrix Metalloproteinase 2 - metabolism ; Medical sciences ; MMP ; Neoplasm Invasiveness ; Neoplasm Staging ; Neovascularization, Pathologic - metabolism ; Neovascularization, Pathologic - pathology ; Ovarian carcinoma ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology ; Pharmacology. Drug treatments ; Phenotype ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; Survival Analysis ; Tumors ; Vascular Endothelial Growth Factor C - genetics ; Vascular Endothelial Growth Factor C - immunology ; Vascular Endothelial Growth Factor C - metabolism ; VEGF-C</subject><ispartof>Clinical cancer research, 2005-05, Vol.11 (9), p.3225-3232</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-1e3e99b5543c801223f153ec13d836173b788adcf64f91566c2b7846f0764b3e3</citedby><cites>FETCH-LOGICAL-c514t-1e3e99b5543c801223f153ec13d836173b788adcf64f91566c2b7846f0764b3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16738049$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15867217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>UEDA, Masatsugu</creatorcontrib><creatorcontrib>HUNG, Yao-Ching</creatorcontrib><creatorcontrib>TERAI, Yoshito</creatorcontrib><creatorcontrib>KANDA, Koji</creatorcontrib><creatorcontrib>KANEMURA, Masanori</creatorcontrib><creatorcontrib>FUTAKUCHI, Hikari</creatorcontrib><creatorcontrib>YAMAGUCHI, Hiroyuki</creatorcontrib><creatorcontrib>AKISE, Daisuke</creatorcontrib><creatorcontrib>YASUDA, Masayuki</creatorcontrib><creatorcontrib>UEKI, Minoru</creatorcontrib><title>Vascular Endothelial Growth Factor-C Expression and Invasive Phenotype in Ovarian Carcinomas</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: To investigate the biological correlation between vascular endothelial growth factor (VEGF)-C expression and invasive phenotype
in ovarian carcinomas.
Experimental Design: Gene and protein expression levels of VEGF-C in 10 ovarian carcinoma cell lines were correlated with invasive activity of
the cells. The correlation between immunohistochemical expression of VEGF-C and tumor aggressiveness in 73 ovarian carcinomas
was also examined with respect to clinicopathologic features and patient outcome.
Results: VEGF-C gene and protein expression differed remarkably among the cell lines, and there was a statistical correlation among VEGF-C
expression, in vitro invasive activity, and matrix metalloproteinase-2 ( MMP-2 ) gene expression and its activity. Anti-VEGF-C and anti-MMP-2 antibodies inhibited the invasive activity of tumor cells.
VEGF-C expression in clinical tissue samples was well correlated with clinical stages, retroperitoneal lymph node metastasis,
MMP-2 expression, angiogenesis, lymphangiogenesis, and low apoptotic index (AI). The patients whose tumors had strong VEGF-C
expression and low AI underwent a poorer prognosis than did those with weak VEGF-C expression and high AI.
Conclusion: VEGF-C expression is closely related to invasive phenotype and affects the patient's survival in ovarian carcinomas.</description><subject>Angiogenesis</subject><subject>Antibodies - pharmacology</subject><subject>Antigens, CD34 - analysis</subject><subject>Antineoplastic agents</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Nick-End Labeling</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Medical sciences</subject><subject>MMP</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Ovarian carcinoma</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Prognosis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Survival Analysis</subject><subject>Tumors</subject><subject>Vascular Endothelial Growth Factor C - genetics</subject><subject>Vascular Endothelial Growth Factor C - immunology</subject><subject>Vascular Endothelial Growth Factor C - metabolism</subject><subject>VEGF-C</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhgdRbK3-BCU3ijdTc_I9lzJsa6FQEfVKCNnMGScym6zJ7Nb-e7PsSi-9ykt4znnhOU3zGuglgDQfgGrTUsHZZd9_qaEFEOZJcw5S6pYzJZ_W_I85a16U8otSEEDF8-asLlCagT5vfnx3xe9ml8kqDmmZcA5uJtc53S8TuXJ-SbntyerPNmMpIUXi4kBu4t6VsEfyecKYloctkhDJ3d7l4CLpXfYhpo0rL5tno5sLvjq9F823q9XX_lN7e3d903-8bb0EsbSAHLtuLaXg3lBgjI8gOXrgg-EKNF9rY9zgRyXGDqRSntUfoUaqlVhz5BfNu-PebU6_d1gWuwnF4zy7iGlXrNLaaBDiv2DtEpIBraA8gj6nUjKOdpvDxuUHC9Qe_NuDW3twa6v_GuzBf517cyrYrTc4PE6dhFfg7Qmo3t08Zhd9KI-c0txQ0VXu_ZGbws_pPmS0vpKY6xmw-p1qne0sZ0zyv7Aomvc</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>UEDA, Masatsugu</creator><creator>HUNG, Yao-Ching</creator><creator>TERAI, Yoshito</creator><creator>KANDA, Koji</creator><creator>KANEMURA, Masanori</creator><creator>FUTAKUCHI, Hikari</creator><creator>YAMAGUCHI, Hiroyuki</creator><creator>AKISE, Daisuke</creator><creator>YASUDA, Masayuki</creator><creator>UEKI, Minoru</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Vascular Endothelial Growth Factor-C Expression and Invasive Phenotype in Ovarian Carcinomas</title><author>UEDA, Masatsugu ; HUNG, Yao-Ching ; TERAI, Yoshito ; KANDA, Koji ; KANEMURA, Masanori ; FUTAKUCHI, Hikari ; YAMAGUCHI, Hiroyuki ; AKISE, Daisuke ; YASUDA, Masayuki ; UEKI, Minoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-1e3e99b5543c801223f153ec13d836173b788adcf64f91566c2b7846f0764b3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Angiogenesis</topic><topic>Antibodies - pharmacology</topic><topic>Antigens, CD34 - analysis</topic><topic>Antineoplastic agents</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Nick-End Labeling</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Medical sciences</topic><topic>MMP</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Ovarian carcinoma</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>Prognosis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Survival Analysis</topic><topic>Tumors</topic><topic>Vascular Endothelial Growth Factor C - genetics</topic><topic>Vascular Endothelial Growth Factor C - immunology</topic><topic>Vascular Endothelial Growth Factor C - metabolism</topic><topic>VEGF-C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>UEDA, Masatsugu</creatorcontrib><creatorcontrib>HUNG, Yao-Ching</creatorcontrib><creatorcontrib>TERAI, Yoshito</creatorcontrib><creatorcontrib>KANDA, Koji</creatorcontrib><creatorcontrib>KANEMURA, Masanori</creatorcontrib><creatorcontrib>FUTAKUCHI, Hikari</creatorcontrib><creatorcontrib>YAMAGUCHI, Hiroyuki</creatorcontrib><creatorcontrib>AKISE, Daisuke</creatorcontrib><creatorcontrib>YASUDA, Masayuki</creatorcontrib><creatorcontrib>UEKI, Minoru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UEDA, Masatsugu</au><au>HUNG, Yao-Ching</au><au>TERAI, Yoshito</au><au>KANDA, Koji</au><au>KANEMURA, Masanori</au><au>FUTAKUCHI, Hikari</au><au>YAMAGUCHI, Hiroyuki</au><au>AKISE, Daisuke</au><au>YASUDA, Masayuki</au><au>UEKI, Minoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular Endothelial Growth Factor-C Expression and Invasive Phenotype in Ovarian Carcinomas</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>11</volume><issue>9</issue><spage>3225</spage><epage>3232</epage><pages>3225-3232</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: To investigate the biological correlation between vascular endothelial growth factor (VEGF)-C expression and invasive phenotype
in ovarian carcinomas.
Experimental Design: Gene and protein expression levels of VEGF-C in 10 ovarian carcinoma cell lines were correlated with invasive activity of
the cells. The correlation between immunohistochemical expression of VEGF-C and tumor aggressiveness in 73 ovarian carcinomas
was also examined with respect to clinicopathologic features and patient outcome.
Results: VEGF-C gene and protein expression differed remarkably among the cell lines, and there was a statistical correlation among VEGF-C
expression, in vitro invasive activity, and matrix metalloproteinase-2 ( MMP-2 ) gene expression and its activity. Anti-VEGF-C and anti-MMP-2 antibodies inhibited the invasive activity of tumor cells.
VEGF-C expression in clinical tissue samples was well correlated with clinical stages, retroperitoneal lymph node metastasis,
MMP-2 expression, angiogenesis, lymphangiogenesis, and low apoptotic index (AI). The patients whose tumors had strong VEGF-C
expression and low AI underwent a poorer prognosis than did those with weak VEGF-C expression and high AI.
Conclusion: VEGF-C expression is closely related to invasive phenotype and affects the patient's survival in ovarian carcinomas.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15867217</pmid><doi>10.1158/1078-0432.CCR-04-1148</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 2005-05, Vol.11 (9), p.3225-3232 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67787144 |
| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Angiogenesis Antibodies - pharmacology Antigens, CD34 - analysis Antineoplastic agents Apoptosis Biological and medical sciences Cell Line, Tumor Cell Movement - drug effects Dose-Response Relationship, Drug Female Female genital diseases Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Immunohistochemistry In Situ Nick-End Labeling Matrix Metalloproteinase 2 - metabolism Medical sciences MMP Neoplasm Invasiveness Neoplasm Staging Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pharmacology. Drug treatments Phenotype Prognosis Reverse Transcriptase Polymerase Chain Reaction Survival Analysis Tumors Vascular Endothelial Growth Factor C - genetics Vascular Endothelial Growth Factor C - immunology Vascular Endothelial Growth Factor C - metabolism VEGF-C |
| title | Vascular Endothelial Growth Factor-C Expression and Invasive Phenotype in Ovarian Carcinomas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T06%3A50%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vascular%20Endothelial%20Growth%20Factor-C%20Expression%20and%20Invasive%20Phenotype%20in%20Ovarian%20Carcinomas&rft.jtitle=Clinical%20cancer%20research&rft.au=UEDA,%20Masatsugu&rft.date=2005-05-01&rft.volume=11&rft.issue=9&rft.spage=3225&rft.epage=3232&rft.pages=3225-3232&rft.issn=1078-0432&rft.eissn=1557-3265&rft_id=info:doi/10.1158/1078-0432.CCR-04-1148&rft_dat=%3Cproquest_cross%3E67787144%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17345210&rft_id=info:pmid/15867217&rfr_iscdi=true |