Late Cornified Envelope Family in Differentiating Epithelia—Response to Calcium and Ultraviolet Irradiation

The late cornified envelope (LCE) gene cluster within the epidermal differentiation complex on human chromosome one (mouse chromosome three) contains multiple conserved genes encoding stratum-corneum proteins. Within the LCE cluster, genes form “groups” based on chromosomal position and protein homo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of investigative dermatology 2005-05, Vol.124 (5), p.1062-1070
Hauptverfasser: Jackson, Benjamin, Tilli, Claudia M.L.J., Hardman, Matthew J., Avilion, Ariel A., MacLeod, Michael C., Ashcroft, Gillian S., Byrne, Carolyn
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1070
container_issue 5
container_start_page 1062
container_title Journal of investigative dermatology
container_volume 124
creator Jackson, Benjamin
Tilli, Claudia M.L.J.
Hardman, Matthew J.
Avilion, Ariel A.
MacLeod, Michael C.
Ashcroft, Gillian S.
Byrne, Carolyn
description The late cornified envelope (LCE) gene cluster within the epidermal differentiation complex on human chromosome one (mouse chromosome three) contains multiple conserved genes encoding stratum-corneum proteins. Within the LCE cluster, genes form “groups” based on chromosomal position and protein homology. We link a recently accepted nomenclature for the LCE cluster (formerly XP5, small proline-rich-like, late-envelope protein genes) to gene structure, groupings, and chromosomal organization, and carry out a pan-cluster quantitative expression analysis in a variety of tissues and environmental conditions. This analysis shows that (i) the cluster organizes into two “skin” expressing groups and a third group with low-level, tissue-specific expression patterns in all barrier-forming epithelia tested, including internal epithelia; (ii) LCE genes respond “group-wise” to environmental stimuli such as calcium levels and ultraviolet (UV) light, highlighting the functional significance of groups; (iii) in response to UV stimulation there is massive upregulation of a single, normally quiescent, non-skin LCE gene; and (iv) heterogeneity occurs between individuals with one individual lacking expression of an LCE skin gene without overt skin disease, suggesting LCE genes affect subtle attributes of skin function. This quantitative and pan-cluster expression analysis suggests that LCE groups have distinct functions and that within groups regulatory diversification permits specific responsiveness to environmental challenge.
doi_str_mv 10.1111/j.0022-202X.2005.23699.x
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67786807</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022202X15322934</els_id><sourcerecordid>67786807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c598t-7b9f3c24f67271ac076d402bbab56218f0f4c4357bcde6ec67e4c13fc11febf53</originalsourceid><addsrcrecordid>eNqFkc1u1DAURiMEokPhEUAWEuwS_Bc7WcIwhUojISEqsbMc5xo8SuzBdkbtjofgCXkSks6oldjUGy_u-a4--xQFIrgi83m3qzCmtKSYfq8oxnVFmWjb6vpRsSI1ZSWRXD4uVnfQWfEspR3GRPC6eVqckbqpOebtqhi3OgNah-idddCjjT_AEPaALvTohhvkPProrIUIPjudnf-BNnuXf8Lg9N_ff75C2gefAOWA1nowbhqR9j26GnLUBxcGyOgyRt0v2eCfF0-sHhK8ON3nxdXF5tv6c7n98uly_X5bmrptcim71jJDuRWSSqINlqLnmHad7mpBSWOx5YazWnamBwFGSOCGMGsIsdDZmp0Xb4979zH8miBlNbpkYBi0hzAlJaRsRIPlgyCRjLNWLODr_8BdmKKfH6EowXMVwpoZao6QiSGlCFbtoxt1vFEEq0Wc2qnFiVqcqEWcuhWnrufoq9P-qRuhvw-eTM3AmxOgk9GDjdobl-450VDMbju8PHJe5ynCHVALTBsi5vmH4xzm_z84iCoZB95A7yKYrPrgHm77Dyjfwtw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>210357138</pqid></control><display><type>article</type><title>Late Cornified Envelope Family in Differentiating Epithelia—Response to Calcium and Ultraviolet Irradiation</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><creator>Jackson, Benjamin ; Tilli, Claudia M.L.J. ; Hardman, Matthew J. ; Avilion, Ariel A. ; MacLeod, Michael C. ; Ashcroft, Gillian S. ; Byrne, Carolyn</creator><creatorcontrib>Jackson, Benjamin ; Tilli, Claudia M.L.J. ; Hardman, Matthew J. ; Avilion, Ariel A. ; MacLeod, Michael C. ; Ashcroft, Gillian S. ; Byrne, Carolyn</creatorcontrib><description>The late cornified envelope (LCE) gene cluster within the epidermal differentiation complex on human chromosome one (mouse chromosome three) contains multiple conserved genes encoding stratum-corneum proteins. Within the LCE cluster, genes form “groups” based on chromosomal position and protein homology. We link a recently accepted nomenclature for the LCE cluster (formerly XP5, small proline-rich-like, late-envelope protein genes) to gene structure, groupings, and chromosomal organization, and carry out a pan-cluster quantitative expression analysis in a variety of tissues and environmental conditions. This analysis shows that (i) the cluster organizes into two “skin” expressing groups and a third group with low-level, tissue-specific expression patterns in all barrier-forming epithelia tested, including internal epithelia; (ii) LCE genes respond “group-wise” to environmental stimuli such as calcium levels and ultraviolet (UV) light, highlighting the functional significance of groups; (iii) in response to UV stimulation there is massive upregulation of a single, normally quiescent, non-skin LCE gene; and (iv) heterogeneity occurs between individuals with one individual lacking expression of an LCE skin gene without overt skin disease, suggesting LCE genes affect subtle attributes of skin function. This quantitative and pan-cluster expression analysis suggests that LCE groups have distinct functions and that within groups regulatory diversification permits specific responsiveness to environmental challenge.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/j.0022-202X.2005.23699.x</identifier><identifier>PMID: 15854049</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Biological and medical sciences ; Calcium - pharmacology ; Cell Differentiation ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Cells, Cultured ; Dermatology ; epidermal differentiation complex ; Epidermis - drug effects ; Epidermis - metabolism ; Epidermis - radiation effects ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - radiation effects ; Humans ; LCE ; Medical sciences ; Molecular and cellular biology ; Multigene Family ; skin barrier ; Terminology as Topic ; ultraviolet ; Ultraviolet Rays</subject><ispartof>Journal of investigative dermatology, 2005-05, Vol.124 (5), p.1062-1070</ispartof><rights>2005 The Society for Investigative Dermatology, Inc</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-7b9f3c24f67271ac076d402bbab56218f0f4c4357bcde6ec67e4c13fc11febf53</citedby><cites>FETCH-LOGICAL-c598t-7b9f3c24f67271ac076d402bbab56218f0f4c4357bcde6ec67e4c13fc11febf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210357138?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=16820338$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15854049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jackson, Benjamin</creatorcontrib><creatorcontrib>Tilli, Claudia M.L.J.</creatorcontrib><creatorcontrib>Hardman, Matthew J.</creatorcontrib><creatorcontrib>Avilion, Ariel A.</creatorcontrib><creatorcontrib>MacLeod, Michael C.</creatorcontrib><creatorcontrib>Ashcroft, Gillian S.</creatorcontrib><creatorcontrib>Byrne, Carolyn</creatorcontrib><title>Late Cornified Envelope Family in Differentiating Epithelia—Response to Calcium and Ultraviolet Irradiation</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>The late cornified envelope (LCE) gene cluster within the epidermal differentiation complex on human chromosome one (mouse chromosome three) contains multiple conserved genes encoding stratum-corneum proteins. Within the LCE cluster, genes form “groups” based on chromosomal position and protein homology. We link a recently accepted nomenclature for the LCE cluster (formerly XP5, small proline-rich-like, late-envelope protein genes) to gene structure, groupings, and chromosomal organization, and carry out a pan-cluster quantitative expression analysis in a variety of tissues and environmental conditions. This analysis shows that (i) the cluster organizes into two “skin” expressing groups and a third group with low-level, tissue-specific expression patterns in all barrier-forming epithelia tested, including internal epithelia; (ii) LCE genes respond “group-wise” to environmental stimuli such as calcium levels and ultraviolet (UV) light, highlighting the functional significance of groups; (iii) in response to UV stimulation there is massive upregulation of a single, normally quiescent, non-skin LCE gene; and (iv) heterogeneity occurs between individuals with one individual lacking expression of an LCE skin gene without overt skin disease, suggesting LCE genes affect subtle attributes of skin function. This quantitative and pan-cluster expression analysis suggests that LCE groups have distinct functions and that within groups regulatory diversification permits specific responsiveness to environmental challenge.</description><subject>Biological and medical sciences</subject><subject>Calcium - pharmacology</subject><subject>Cell Differentiation</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Cells, Cultured</subject><subject>Dermatology</subject><subject>epidermal differentiation complex</subject><subject>Epidermis - drug effects</subject><subject>Epidermis - metabolism</subject><subject>Epidermis - radiation effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - radiation effects</subject><subject>Humans</subject><subject>LCE</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>Multigene Family</subject><subject>skin barrier</subject><subject>Terminology as Topic</subject><subject>ultraviolet</subject><subject>Ultraviolet Rays</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1u1DAURiMEokPhEUAWEuwS_Bc7WcIwhUojISEqsbMc5xo8SuzBdkbtjofgCXkSks6oldjUGy_u-a4--xQFIrgi83m3qzCmtKSYfq8oxnVFmWjb6vpRsSI1ZSWRXD4uVnfQWfEspR3GRPC6eVqckbqpOebtqhi3OgNah-idddCjjT_AEPaALvTohhvkPProrIUIPjudnf-BNnuXf8Lg9N_ff75C2gefAOWA1nowbhqR9j26GnLUBxcGyOgyRt0v2eCfF0-sHhK8ON3nxdXF5tv6c7n98uly_X5bmrptcim71jJDuRWSSqINlqLnmHad7mpBSWOx5YazWnamBwFGSOCGMGsIsdDZmp0Xb4979zH8miBlNbpkYBi0hzAlJaRsRIPlgyCRjLNWLODr_8BdmKKfH6EowXMVwpoZao6QiSGlCFbtoxt1vFEEq0Wc2qnFiVqcqEWcuhWnrufoq9P-qRuhvw-eTM3AmxOgk9GDjdobl-450VDMbju8PHJe5ynCHVALTBsi5vmH4xzm_z84iCoZB95A7yKYrPrgHm77Dyjfwtw</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Jackson, Benjamin</creator><creator>Tilli, Claudia M.L.J.</creator><creator>Hardman, Matthew J.</creator><creator>Avilion, Ariel A.</creator><creator>MacLeod, Michael C.</creator><creator>Ashcroft, Gillian S.</creator><creator>Byrne, Carolyn</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Late Cornified Envelope Family in Differentiating Epithelia—Response to Calcium and Ultraviolet Irradiation</title><author>Jackson, Benjamin ; Tilli, Claudia M.L.J. ; Hardman, Matthew J. ; Avilion, Ariel A. ; MacLeod, Michael C. ; Ashcroft, Gillian S. ; Byrne, Carolyn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-7b9f3c24f67271ac076d402bbab56218f0f4c4357bcde6ec67e4c13fc11febf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Calcium - pharmacology</topic><topic>Cell Differentiation</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Cells, Cultured</topic><topic>Dermatology</topic><topic>epidermal differentiation complex</topic><topic>Epidermis - drug effects</topic><topic>Epidermis - metabolism</topic><topic>Epidermis - radiation effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - radiation effects</topic><topic>Humans</topic><topic>LCE</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>Multigene Family</topic><topic>skin barrier</topic><topic>Terminology as Topic</topic><topic>ultraviolet</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, Benjamin</creatorcontrib><creatorcontrib>Tilli, Claudia M.L.J.</creatorcontrib><creatorcontrib>Hardman, Matthew J.</creatorcontrib><creatorcontrib>Avilion, Ariel A.</creatorcontrib><creatorcontrib>MacLeod, Michael C.</creatorcontrib><creatorcontrib>Ashcroft, Gillian S.</creatorcontrib><creatorcontrib>Byrne, Carolyn</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, Benjamin</au><au>Tilli, Claudia M.L.J.</au><au>Hardman, Matthew J.</au><au>Avilion, Ariel A.</au><au>MacLeod, Michael C.</au><au>Ashcroft, Gillian S.</au><au>Byrne, Carolyn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Late Cornified Envelope Family in Differentiating Epithelia—Response to Calcium and Ultraviolet Irradiation</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>124</volume><issue>5</issue><spage>1062</spage><epage>1070</epage><pages>1062-1070</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>The late cornified envelope (LCE) gene cluster within the epidermal differentiation complex on human chromosome one (mouse chromosome three) contains multiple conserved genes encoding stratum-corneum proteins. Within the LCE cluster, genes form “groups” based on chromosomal position and protein homology. We link a recently accepted nomenclature for the LCE cluster (formerly XP5, small proline-rich-like, late-envelope protein genes) to gene structure, groupings, and chromosomal organization, and carry out a pan-cluster quantitative expression analysis in a variety of tissues and environmental conditions. This analysis shows that (i) the cluster organizes into two “skin” expressing groups and a third group with low-level, tissue-specific expression patterns in all barrier-forming epithelia tested, including internal epithelia; (ii) LCE genes respond “group-wise” to environmental stimuli such as calcium levels and ultraviolet (UV) light, highlighting the functional significance of groups; (iii) in response to UV stimulation there is massive upregulation of a single, normally quiescent, non-skin LCE gene; and (iv) heterogeneity occurs between individuals with one individual lacking expression of an LCE skin gene without overt skin disease, suggesting LCE genes affect subtle attributes of skin function. This quantitative and pan-cluster expression analysis suggests that LCE groups have distinct functions and that within groups regulatory diversification permits specific responsiveness to environmental challenge.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>15854049</pmid><doi>10.1111/j.0022-202X.2005.23699.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0022-202X
ispartof Journal of investigative dermatology, 2005-05, Vol.124 (5), p.1062-1070
issn 0022-202X
1523-1747
language eng
recordid cdi_proquest_miscellaneous_67786807
source MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection
subjects Biological and medical sciences
Calcium - pharmacology
Cell Differentiation
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Cells, Cultured
Dermatology
epidermal differentiation complex
Epidermis - drug effects
Epidermis - metabolism
Epidermis - radiation effects
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Gene Expression Regulation - radiation effects
Humans
LCE
Medical sciences
Molecular and cellular biology
Multigene Family
skin barrier
Terminology as Topic
ultraviolet
Ultraviolet Rays
title Late Cornified Envelope Family in Differentiating Epithelia—Response to Calcium and Ultraviolet Irradiation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A01%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Late%20Cornified%20Envelope%20Family%20in%20Differentiating%20Epithelia%E2%80%94Response%20to%20Calcium%20and%20Ultraviolet%20Irradiation&rft.jtitle=Journal%20of%20investigative%20dermatology&rft.au=Jackson,%20Benjamin&rft.date=2005-05-01&rft.volume=124&rft.issue=5&rft.spage=1062&rft.epage=1070&rft.pages=1062-1070&rft.issn=0022-202X&rft.eissn=1523-1747&rft.coden=JIDEAE&rft_id=info:doi/10.1111/j.0022-202X.2005.23699.x&rft_dat=%3Cproquest_cross%3E67786807%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=210357138&rft_id=info:pmid/15854049&rft_els_id=S0022202X15322934&rfr_iscdi=true