Effects of Intramyocardial Administration of Slow-Release Basic Fibroblast Growth Factor on Angiogenesis and Ventricular Remodeling in a Rat Infarct Model

Background Basic fibroblast growth factor (bFGF) stimulates neoangiogenesis. Incorporation into biodegradable gelatin hydrogels provides the sustained release of bFGF. The effects of intramyocardial injections of slow-release bFGF on neoangiogenesis in a rat model of infarction were investigated. Me...

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Veröffentlicht in:	Circulation Journal 2006, Vol.70(4), pp.471-477
Hauptverfasser:	Shao, Zhan-Qiang, Takaji, Kentaro, Katayama, Yukihiro, Kunitomo, Ryuji, Sakaguchi, Hisashi, Lai, Zhong-Fang, Kawasuji, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Capillaries - pathology Delayed-Action Preparations Echocardiography Fibroblast Growth Factor 2 - administration & dosage Fibroblast Growth Factor 2 - pharmacology Fibroblast Growth Factor 2 - therapeutic use Hydrogels Ischemic heart disease Male Myocardial Infarction - drug therapy Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial remodeling Neovascularization, Physiologic - drug effects Rats Rats, Sprague-Dawley Ventricular Function Ventricular Remodeling - drug effects
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