Respiratory Failure and Hypercoagulability in a Toddler With Lemierre's Syndrome
A 3.5-year-old healthy boy with 4 days of fever was referred to the emergency department for respiratory distress. The physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. Initial blood tests showed pancytopenia. He rapidly developed torticollis. Computerized tomograp...
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| Veröffentlicht in: | Pediatrics (Evanston) 2005-05, Vol.115 (5), p.e620-e622 |
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| creator | Schmid, Tal Miskin, Hagit Schlesinger, Yechiel Argaman, Zvi Kleid, David |
| description | A 3.5-year-old healthy boy with 4 days of fever was referred to the emergency department for respiratory distress. The physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. Initial blood tests showed pancytopenia. He rapidly developed torticollis. Computerized tomography of the neck revealed a thrombus in the internal jugular vein. A presumptive diagnosis of Lemierre's syndrome was made and he was started on antibiotics and anticoagulation. He subsequently developed adult respiratory distress syndrome and required high frequency oscillatory ventilation for 9 days. Blood cultures were positive for Fusobacterium necrophorum. Screening for hypercoagulability revealed 2 known risk factors: a mutation in the prothrombin gene and elevated lipoprotein a. |
| doi_str_mv | 10.1542/peds.2004-2505 |
| format | Article |
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The physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. Initial blood tests showed pancytopenia. He rapidly developed torticollis. Computerized tomography of the neck revealed a thrombus in the internal jugular vein. A presumptive diagnosis of Lemierre's syndrome was made and he was started on antibiotics and anticoagulation. He subsequently developed adult respiratory distress syndrome and required high frequency oscillatory ventilation for 9 days. Blood cultures were positive for Fusobacterium necrophorum. Screening for hypercoagulability revealed 2 known risk factors: a mutation in the prothrombin gene and elevated lipoprotein a.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2004-2505</identifier><identifier>PMID: 15833890</identifier><language>eng</language><publisher>United States: Am Acad Pediatrics</publisher><subject>Child, Preschool ; Fusobacterium Infections - complications ; Fusobacterium Infections - diagnosis ; Fusobacterium necrophorum ; Fusobacterium necrophorum - isolation & purification ; Humans ; Jugular Veins - diagnostic imaging ; Male ; Mutation ; Respiratory Distress Syndrome, Adult - etiology ; Respiratory Insufficiency - etiology ; Syndrome ; Thrombophilia - complications ; Thrombophilia - diagnosis ; Thrombophilia - genetics ; Thrombophlebitis - complications ; Thrombophlebitis - diagnostic imaging ; Tomography, X-Ray Computed ; Torticollis - etiology</subject><ispartof>Pediatrics (Evanston), 2005-05, Vol.115 (5), p.e620-e622</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-47a97924ef5650f0fb211a5b5816d7f4af2b07b738878522185478eb6bdc0ff33</citedby><cites>FETCH-LOGICAL-c364t-47a97924ef5650f0fb211a5b5816d7f4af2b07b738878522185478eb6bdc0ff33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15833890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmid, Tal</creatorcontrib><creatorcontrib>Miskin, Hagit</creatorcontrib><creatorcontrib>Schlesinger, Yechiel</creatorcontrib><creatorcontrib>Argaman, Zvi</creatorcontrib><creatorcontrib>Kleid, David</creatorcontrib><title>Respiratory Failure and Hypercoagulability in a Toddler With Lemierre's Syndrome</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>A 3.5-year-old healthy boy with 4 days of fever was referred to the emergency department for respiratory distress. The physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. Initial blood tests showed pancytopenia. He rapidly developed torticollis. Computerized tomography of the neck revealed a thrombus in the internal jugular vein. A presumptive diagnosis of Lemierre's syndrome was made and he was started on antibiotics and anticoagulation. He subsequently developed adult respiratory distress syndrome and required high frequency oscillatory ventilation for 9 days. Blood cultures were positive for Fusobacterium necrophorum. Screening for hypercoagulability revealed 2 known risk factors: a mutation in the prothrombin gene and elevated lipoprotein a.</description><subject>Child, Preschool</subject><subject>Fusobacterium Infections - complications</subject><subject>Fusobacterium Infections - diagnosis</subject><subject>Fusobacterium necrophorum</subject><subject>Fusobacterium necrophorum - isolation & purification</subject><subject>Humans</subject><subject>Jugular Veins - diagnostic imaging</subject><subject>Male</subject><subject>Mutation</subject><subject>Respiratory Distress Syndrome, Adult - etiology</subject><subject>Respiratory Insufficiency - etiology</subject><subject>Syndrome</subject><subject>Thrombophilia - complications</subject><subject>Thrombophilia - diagnosis</subject><subject>Thrombophilia - genetics</subject><subject>Thrombophlebitis - complications</subject><subject>Thrombophlebitis - diagnostic imaging</subject><subject>Tomography, X-Ray Computed</subject><subject>Torticollis - etiology</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0L9v1DAYxnELUdGjsDIiT3TK9fWPN3ZGVFGKdBIVFDFaTvK6Z5Rcgp0I5b_vRXcSbEz28Hmf4cvYOwFbgVrejNTmrQTQhUTAF2wjoLKFlgZfsg2AEoUGwEv2OudfcGRo5Ct2KdAqZSvYsIdvlMeY_DSkhd_52M2JuD-0_H4ZKTWDf5o7X8cuTguPB-7549C2HSX-M057vqM-Ukp0nfn35dCmoac37CL4LtPb83vFftx9ery9L3ZfP3-5_bgrGlXqqdDGV6aSmgKWCAFCLYXwWKMVZWuC9kHWYGqjrDUWpRQWtbFUl3XbQAhKXbEPp90xDb9nypPrY26o6_yBhjm70hhbosX_QimUqipbHeH2BJs05JwouDHF3qfFCXBrbLfGdmtst8Y-Hrw_L891T-1ffq57BDcnsI9P-z8x0boQ_ZRik__5CoEOHZUS1DNRTItr</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Schmid, Tal</creator><creator>Miskin, Hagit</creator><creator>Schlesinger, Yechiel</creator><creator>Argaman, Zvi</creator><creator>Kleid, David</creator><general>Am Acad Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Respiratory Failure and Hypercoagulability in a Toddler With Lemierre's Syndrome</title><author>Schmid, Tal ; Miskin, Hagit ; Schlesinger, Yechiel ; Argaman, Zvi ; Kleid, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-47a97924ef5650f0fb211a5b5816d7f4af2b07b738878522185478eb6bdc0ff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Child, Preschool</topic><topic>Fusobacterium Infections - complications</topic><topic>Fusobacterium Infections - diagnosis</topic><topic>Fusobacterium necrophorum</topic><topic>Fusobacterium necrophorum - isolation & purification</topic><topic>Humans</topic><topic>Jugular Veins - diagnostic imaging</topic><topic>Male</topic><topic>Mutation</topic><topic>Respiratory Distress Syndrome, Adult - etiology</topic><topic>Respiratory Insufficiency - etiology</topic><topic>Syndrome</topic><topic>Thrombophilia - complications</topic><topic>Thrombophilia - diagnosis</topic><topic>Thrombophilia - genetics</topic><topic>Thrombophlebitis - complications</topic><topic>Thrombophlebitis - diagnostic imaging</topic><topic>Tomography, X-Ray Computed</topic><topic>Torticollis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmid, Tal</creatorcontrib><creatorcontrib>Miskin, Hagit</creatorcontrib><creatorcontrib>Schlesinger, Yechiel</creatorcontrib><creatorcontrib>Argaman, Zvi</creatorcontrib><creatorcontrib>Kleid, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmid, Tal</au><au>Miskin, Hagit</au><au>Schlesinger, Yechiel</au><au>Argaman, Zvi</au><au>Kleid, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory Failure and Hypercoagulability in a Toddler With Lemierre's Syndrome</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>115</volume><issue>5</issue><spage>e620</spage><epage>e622</epage><pages>e620-e622</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>A 3.5-year-old healthy boy with 4 days of fever was referred to the emergency department for respiratory distress. The physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. Initial blood tests showed pancytopenia. He rapidly developed torticollis. Computerized tomography of the neck revealed a thrombus in the internal jugular vein. A presumptive diagnosis of Lemierre's syndrome was made and he was started on antibiotics and anticoagulation. He subsequently developed adult respiratory distress syndrome and required high frequency oscillatory ventilation for 9 days. Blood cultures were positive for Fusobacterium necrophorum. Screening for hypercoagulability revealed 2 known risk factors: a mutation in the prothrombin gene and elevated lipoprotein a.</abstract><cop>United States</cop><pub>Am Acad Pediatrics</pub><pmid>15833890</pmid><doi>10.1542/peds.2004-2505</doi></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Child, Preschool Fusobacterium Infections - complications Fusobacterium Infections - diagnosis Fusobacterium necrophorum Fusobacterium necrophorum - isolation & purification Humans Jugular Veins - diagnostic imaging Male Mutation Respiratory Distress Syndrome, Adult - etiology Respiratory Insufficiency - etiology Syndrome Thrombophilia - complications Thrombophilia - diagnosis Thrombophilia - genetics Thrombophlebitis - complications Thrombophlebitis - diagnostic imaging Tomography, X-Ray Computed Torticollis - etiology |
| title | Respiratory Failure and Hypercoagulability in a Toddler With Lemierre's Syndrome |
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