Similar Impact of Slow and Delayed Graft Function on Renal Allograft Outcome and Function
Kidney transplant patients can be divided into three groups, according to the initial graft function. First-week dialyzed patients form the delayed graft function (DGF) group. Nondialyzed patients are divided into slow graft function (SGF) or immediate graft function (IGF) according to whether the d...
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| Veröffentlicht in: | Transplantation proceedings 2005-04, Vol.37 (3), p.1431-1432 |
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| creator | Rodrigo, E. Fernández-Fresnedo, G. Ruiz, J.C. Piñera, C. Palomar, R. González-Cotorruelo, J. Zubimendi, J.A. De Francisco, A.L.M. Sanz de Castro, S. Arias, M. |
| description | Kidney transplant patients can be divided into three groups, according to the initial graft function. First-week dialyzed patients form the delayed graft function (DGF) group. Nondialyzed patients are divided into slow graft function (SGF) or immediate graft function (IGF) according to whether the day 5 serum creatinine was higher versus lower than 3 mg/dL, respectively. SGF patients showed worse graft survival, above higher incidence of acute rejection and lower renal function than IGF patients, although few reports have analyzed outcomes in these groups. We analyzed the impact of SGF on graft survival, first-year renal function, and incidence of acute rejection in 291 renal transplant patients. Creatinine was significantly worse at 12 months for SGF and DGF than for IGF patients (1.9 ± 0.8 mg/dL, 1.8 ± 0.7 mg/dL, 1.5 ± 0.5 mg/dL, respectively;
P < .05). There was no difference in first-year renal function between SGF and DGF. The acute rejection rate was higher among the SGF than the IGF group (45% vs 21%,
P < .05), but not different from DGF patients (42%,
P < .05). Graft survival was better among IGF than SGF or DGF patients, with no significant difference between the last two groups (3-year graft survival, 82%, 71%, 70%, respectively; log-rank test,
P < .05). Kidney transplant recipients who develop SGF have a worse outcome than patients with IGF, similar to DGF patients. SGF patients show worse graft survival, worse renal function, and higher acute rejection rates than IGF patients, despite not needing dialysis. |
| doi_str_mv | 10.1016/j.transproceed.2005.02.052 |
| format | Article |
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P < .05). There was no difference in first-year renal function between SGF and DGF. The acute rejection rate was higher among the SGF than the IGF group (45% vs 21%,
P < .05), but not different from DGF patients (42%,
P < .05). Graft survival was better among IGF than SGF or DGF patients, with no significant difference between the last two groups (3-year graft survival, 82%, 71%, 70%, respectively; log-rank test,
P < .05). Kidney transplant recipients who develop SGF have a worse outcome than patients with IGF, similar to DGF patients. SGF patients show worse graft survival, worse renal function, and higher acute rejection rates than IGF patients, despite not needing dialysis.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2005.02.052</identifier><identifier>PMID: 15866627</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Creatinine - blood ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Rejection - epidemiology ; Graft Survival - physiology ; Humans ; Isoantibodies - blood ; Kidney Transplantation - physiology ; Medical sciences ; Middle Aged ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors ; Tissue, organ and graft immunology ; Transplantation, Homologous ; Treatment Outcome</subject><ispartof>Transplantation proceedings, 2005-04, Vol.37 (3), p.1431-1432</ispartof><rights>2005 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-e9db51c2b90a3a2a9e8c282001a657a809aba1d4b756a45d15a2a9ac9a0738503</citedby><cites>FETCH-LOGICAL-c408t-e9db51c2b90a3a2a9e8c282001a657a809aba1d4b756a45d15a2a9ac9a0738503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2005.02.052$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16790491$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15866627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodrigo, E.</creatorcontrib><creatorcontrib>Fernández-Fresnedo, G.</creatorcontrib><creatorcontrib>Ruiz, J.C.</creatorcontrib><creatorcontrib>Piñera, C.</creatorcontrib><creatorcontrib>Palomar, R.</creatorcontrib><creatorcontrib>González-Cotorruelo, J.</creatorcontrib><creatorcontrib>Zubimendi, J.A.</creatorcontrib><creatorcontrib>De Francisco, A.L.M.</creatorcontrib><creatorcontrib>Sanz de Castro, S.</creatorcontrib><creatorcontrib>Arias, M.</creatorcontrib><title>Similar Impact of Slow and Delayed Graft Function on Renal Allograft Outcome and Function</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Kidney transplant patients can be divided into three groups, according to the initial graft function. First-week dialyzed patients form the delayed graft function (DGF) group. Nondialyzed patients are divided into slow graft function (SGF) or immediate graft function (IGF) according to whether the day 5 serum creatinine was higher versus lower than 3 mg/dL, respectively. SGF patients showed worse graft survival, above higher incidence of acute rejection and lower renal function than IGF patients, although few reports have analyzed outcomes in these groups. We analyzed the impact of SGF on graft survival, first-year renal function, and incidence of acute rejection in 291 renal transplant patients. Creatinine was significantly worse at 12 months for SGF and DGF than for IGF patients (1.9 ± 0.8 mg/dL, 1.8 ± 0.7 mg/dL, 1.5 ± 0.5 mg/dL, respectively;
P < .05). There was no difference in first-year renal function between SGF and DGF. The acute rejection rate was higher among the SGF than the IGF group (45% vs 21%,
P < .05), but not different from DGF patients (42%,
P < .05). Graft survival was better among IGF than SGF or DGF patients, with no significant difference between the last two groups (3-year graft survival, 82%, 71%, 70%, respectively; log-rank test,
P < .05). Kidney transplant recipients who develop SGF have a worse outcome than patients with IGF, similar to DGF patients. SGF patients show worse graft survival, worse renal function, and higher acute rejection rates than IGF patients, despite not needing dialysis.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Creatinine - blood</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Survival - physiology</subject><subject>Humans</subject><subject>Isoantibodies - blood</subject><subject>Kidney Transplantation - physiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhLyALCW4JYyd2Em5VS0ulSpUoHDhZE2eCvHLixU6K-u_xdpePI5KlkTXPO_Y8jL0RUAoQ-v22XCLOaReDJRpKCaBKkCUo-YRtRNtUhdSyeso2ALUoRFWrE_YipS3ku6yr5-xEqFZrLZsN-3bnJucx8utph3bhYeR3PvzkOA_8gjw-0MCvIo4Lv1xnu7gw83w-04yen3kfvj_2btfFhokeU7-5l-zZiD7Rq2M9ZV8vP345_1Tc3F5dn5_dFLaGdimoG3olrOw7wAoldtRa2eadBGrVYAsd9iiGum-UxloNQu0htB1CU7UKqlP27jA3-_ixUlrM5JIl73GmsCajm6bVVVdn8MMBtDGkFGk0u-gmjA9GgNmLNVvzr1izF2tAmiw2h18fX1n7Kff-RI8mM_D2CGCy6Mc8yLr0l9NNB3UnMndx4Cg7uXcUTbKOZkuDi2QXMwT3P__5BVY4nVM</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Rodrigo, E.</creator><creator>Fernández-Fresnedo, G.</creator><creator>Ruiz, J.C.</creator><creator>Piñera, C.</creator><creator>Palomar, R.</creator><creator>González-Cotorruelo, J.</creator><creator>Zubimendi, J.A.</creator><creator>De Francisco, A.L.M.</creator><creator>Sanz de Castro, S.</creator><creator>Arias, M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Similar Impact of Slow and Delayed Graft Function on Renal Allograft Outcome and Function</title><author>Rodrigo, E. ; Fernández-Fresnedo, G. ; Ruiz, J.C. ; Piñera, C. ; Palomar, R. ; González-Cotorruelo, J. ; Zubimendi, J.A. ; De Francisco, A.L.M. ; Sanz de Castro, S. ; Arias, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-e9db51c2b90a3a2a9e8c282001a657a809aba1d4b756a45d15a2a9ac9a0738503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Creatinine - blood</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Survival - physiology</topic><topic>Humans</topic><topic>Isoantibodies - blood</topic><topic>Kidney Transplantation - physiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodrigo, E.</creatorcontrib><creatorcontrib>Fernández-Fresnedo, G.</creatorcontrib><creatorcontrib>Ruiz, J.C.</creatorcontrib><creatorcontrib>Piñera, C.</creatorcontrib><creatorcontrib>Palomar, R.</creatorcontrib><creatorcontrib>González-Cotorruelo, J.</creatorcontrib><creatorcontrib>Zubimendi, J.A.</creatorcontrib><creatorcontrib>De Francisco, A.L.M.</creatorcontrib><creatorcontrib>Sanz de Castro, S.</creatorcontrib><creatorcontrib>Arias, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodrigo, E.</au><au>Fernández-Fresnedo, G.</au><au>Ruiz, J.C.</au><au>Piñera, C.</au><au>Palomar, R.</au><au>González-Cotorruelo, J.</au><au>Zubimendi, J.A.</au><au>De Francisco, A.L.M.</au><au>Sanz de Castro, S.</au><au>Arias, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Similar Impact of Slow and Delayed Graft Function on Renal Allograft Outcome and Function</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>37</volume><issue>3</issue><spage>1431</spage><epage>1432</epage><pages>1431-1432</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Kidney transplant patients can be divided into three groups, according to the initial graft function. First-week dialyzed patients form the delayed graft function (DGF) group. Nondialyzed patients are divided into slow graft function (SGF) or immediate graft function (IGF) according to whether the day 5 serum creatinine was higher versus lower than 3 mg/dL, respectively. SGF patients showed worse graft survival, above higher incidence of acute rejection and lower renal function than IGF patients, although few reports have analyzed outcomes in these groups. We analyzed the impact of SGF on graft survival, first-year renal function, and incidence of acute rejection in 291 renal transplant patients. Creatinine was significantly worse at 12 months for SGF and DGF than for IGF patients (1.9 ± 0.8 mg/dL, 1.8 ± 0.7 mg/dL, 1.5 ± 0.5 mg/dL, respectively;
P < .05). There was no difference in first-year renal function between SGF and DGF. The acute rejection rate was higher among the SGF than the IGF group (45% vs 21%,
P < .05), but not different from DGF patients (42%,
P < .05). Graft survival was better among IGF than SGF or DGF patients, with no significant difference between the last two groups (3-year graft survival, 82%, 71%, 70%, respectively; log-rank test,
P < .05). Kidney transplant recipients who develop SGF have a worse outcome than patients with IGF, similar to DGF patients. SGF patients show worse graft survival, worse renal function, and higher acute rejection rates than IGF patients, despite not needing dialysis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15866627</pmid><doi>10.1016/j.transproceed.2005.02.052</doi><tpages>2</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Creatinine - blood Follow-Up Studies Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - epidemiology Graft Survival - physiology Humans Isoantibodies - blood Kidney Transplantation - physiology Medical sciences Middle Aged Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Tissue, organ and graft immunology Transplantation, Homologous Treatment Outcome |
| title | Similar Impact of Slow and Delayed Graft Function on Renal Allograft Outcome and Function |
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