Disease association of two distinct interleukin-18 promoter polymorphisms in Caucasian rheumatoid arthritis patients

Interleukin (IL)-18 is an important mediator of innate and adaptive immunity. We searched for an association of IL-18 promoter single-nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) in Caucasians. The entire study population was composed of two independent cohorts from Germany ( n =200...

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Veröffentlicht in:	Genes and immunity 2005-05, Vol.6 (3), p.211-216
Hauptverfasser:	Gracie, J A, Koyama, N, Murdoch, J, Field, M, McGarry, F, Crilly, A, Schobel, A, Madhok, R, Pons-Kühnemann, J, McInnes, I B, Möller, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Cytokines Disease European Continental Ancestry Group full-paper Gene Expression Genes Genetic aspects Genetic polymorphisms Germany Haplotypes Human Genetics Humans Immunology Interleukin 18 Interleukin-18 - genetics Interleukin-18 - metabolism Interleukins Linkage disequilibrium Lymphocytes Pathogenesis Physiological aspects Polymorphism Polymorphism, Genetic Population studies Promoter Regions, Genetic Rheumatoid arthritis Risk factors Scotland Single-nucleotide polymorphism Statistical significance Tumor necrosis factor-TNF White people
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