Pterostilbene, a New Agonist for the Peroxisome Proliferator-Activated Receptor α-Isoform, Lowers Plasma Lipoproteins and Cholesterol in Hypercholesterolemic Hamsters

Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts and other berries, has been reported to have hypolipidemic properties. We investigated whether resveratrol and its three analogues (pterostilbene, piceatannol, and resveratrol trimethyl ether) would activate the peroxisome prolifer...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2005-05, Vol.53 (9), p.3403-3407
Hauptverfasser:	Rimando, Agnes M, Nagmani, Rangaswamy, Feller, Dennis R, Yokoyama, Wallace
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Oxidase - genetics agonists Animals Biological and medical sciences blood plasma cholesterol Cholesterol - blood Cricetinae gene expression gene induction General and cellular metabolism. Vitamins grapes hamsters high density lipoprotein hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - drug therapy lipemic effect Lipoproteins - blood Liver Neoplasms, Experimental low density lipoprotein luciferase Male Medical sciences Mesocricetus Pharmacology. Drug treatments Phenols - administration & dosage piceatannol PPAR alpha - agonists PPAR alpha - genetics pterostilbene Rats receptors Recombinant Fusion Proteins reporter genes Response Elements - genetics resveratrol resveratrol trimethyl ether stilbenes Stilbenes - administration & dosage transcription factors Transfection Tumor Cells, Cultured
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