Postischemic Brain Injury Is Exacerbated in Mice Lacking the Kinin B2 Receptor

Kallikrein cleaves low molecular weight kininogen to generate vasoactive kinins, which bind to the kinin B2 receptor, triggering a host of biological effects. Kallikrein gene delivery has been shown previously to reduce ischemia/reperfusion-induced cerebral infarction. In this study, we tested the h...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2006-04, Vol.47 (4), p.752-761
Hauptverfasser:	Xia, Chun-Fang, Smith, Robert S, Shen, Bo, Yang, Zhi-Rong, Borlongan, Cesar V, Chao, Lee, Chao, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Arterial hypertension. Arterial hypotension Biochemistry and metabolism Biological and medical sciences Blood and lymphatic vessels Brain - metabolism Brain - physiopathology Brain Ischemia - complications Brain Ischemia - mortality Brain Ischemia - pathology Brain Ischemia - physiopathology Cardiology. Vascular system Central nervous system Cerebral Infarction - metabolism Cerebral Infarction - pathology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Female Fundamental and applied biological sciences. Psychology Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Multienzyme Complexes - metabolism NADH, NADPH Oxidoreductases - metabolism Nervous System Diseases - etiology Neuroprotective Agents - metabolism Neutrophil Infiltration Nitrates - metabolism Nitrites - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptor, Bradykinin B2 - deficiency Receptor, Bradykinin B2 - metabolism Stroke - mortality Tumor Necrosis Factor-alpha - metabolism Vertebrates: nervous system and sense organs
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