Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

Amyloid {szligbeta} protein (A{szligbeta}) is the principal component of neuritic plaques in Alzheimer's disease (AD). A{szligbeta} is derived from {szligbeta} amyloid precursor protein (APP) by {szligbeta}- and [gamma]-secretases. Beta-site APP cleaving enzyme 1 (BACE1) has been identified as...

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Veröffentlicht in:	The FASEB journal 2005-05, Vol.19 (7), p.739-749
Hauptverfasser:	Sun, Xiulian, Wang, Yingcheng, Qing, Hong, Christensen, Michelle A, Liu, Yunqiang, Zhou, Weihui, Tong, Yigang, Xiao, Cuiying, Huang, Yi, Zhang, Sizhong, Liu, Xiehe, Song, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - enzymology Alzheimer's disease Amino Acid Sequence Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases amyloid β Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - physiology Base Sequence Binding Sites Cell Line Chromosome Mapping Cloning, Molecular DNA - chemistry DNA - metabolism Endopeptidases - genetics Endopeptidases - physiology Gene Expression Regulation, Enzymologic Humans Molecular Sequence Data Neurons - enzymology Plaque, Amyloid - enzymology promoter Promoter Regions, Genetic - genetics secretase Sp1 Transcription Factor - pharmacology Sp1 Transcription Factor - physiology transcription Transcription, Genetic
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