Polo-like kinase isoforms in breast cancer : expression patterns and prognostic implications
Polo-like kinase (PLK) family members are known to be functionally involved in mitotic signaling and in cytoskeletal reorganization in both normal and malignant cells. In this study, expression of PLK1 and PLK3 was determined immunohistochemically in tissue specimens of 135 breast carcinomas, and ex...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2005-04, Vol.446 (4), p.442-450 |
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| creator | WEICHERT, Wilko KRISTIANSEN, Glen WINZER, Klaus-Jürgen SCHMIDT, Mathias GEKELER, Volker NOSKE, Aurelia MÜLLER, Berit-Maria NIESPOREK, Silvia DIETEL, Manfred DENKERT, Carsten |
| description | Polo-like kinase (PLK) family members are known to be functionally involved in mitotic signaling and in cytoskeletal reorganization in both normal and malignant cells. In this study, expression of PLK1 and PLK3 was determined immunohistochemically in tissue specimens of 135 breast carcinomas, and expression was correlated with clinicopathological parameters and patient prognosis. Strong PLK isoform overexpression was observed in 42.2% (PLK1) and 47.4% (PLK3) of breast carcinomas when compared with non-transformed breast tissue. A positive correlation of PLK isoform expression with tumor grade, vascular invasion, erbB2/HER-2 expression and markers of proliferative activity was evident. Additionally, an inverse correlation of PLK isoform expression and estrogen receptor status was observed. Overexpression of PLK3 but not of PLK1 was significantly linked to reduced median overall (P |
| doi_str_mv | 10.1007/s00428-005-1212-8 |
| format | Article |
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In this study, expression of PLK1 and PLK3 was determined immunohistochemically in tissue specimens of 135 breast carcinomas, and expression was correlated with clinicopathological parameters and patient prognosis. Strong PLK isoform overexpression was observed in 42.2% (PLK1) and 47.4% (PLK3) of breast carcinomas when compared with non-transformed breast tissue. A positive correlation of PLK isoform expression with tumor grade, vascular invasion, erbB2/HER-2 expression and markers of proliferative activity was evident. Additionally, an inverse correlation of PLK isoform expression and estrogen receptor status was observed. Overexpression of PLK3 but not of PLK1 was significantly linked to reduced median overall (P<0.001) and relapse-free (P=0.021) survival time. PLK3 expression remained an independent prognostic factor for overall (RR=3.2, P=0.002) and relapse-free (RR=2.9, P=0.049) survival in multivariate survival analysis. These results suggest PLK3 as a novel independent prognostic marker in breast cancer and hint toward a role for PLK isoform overexpression in disease progression. Therefore, in vivo inhibition of PLK family members might represent a rewarding approach in the development of new anticancer drugs for this tumor entity.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-005-1212-8</identifier><identifier>PMID: 15785925</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Breast cancer ; Breast Neoplasms - enzymology ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - enzymology ; Carcinoma, Ductal, Breast - mortality ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Lobular - enzymology ; Carcinoma, Lobular - mortality ; Carcinoma, Lobular - pathology ; Cell Cycle Proteins - metabolism ; Estrogens ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Isoenzymes - metabolism ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Polo-Like Kinase 1 ; Prognosis ; Protein Kinases - metabolism ; Protein Serine-Threonine Kinases - metabolism ; Proto-Oncogene Proteins - metabolism ; Survival Analysis ; Survival Rate ; Tumor Suppressor Proteins ; Tumors</subject><ispartof>Virchows Archiv : an international journal of pathology, 2005-04, Vol.446 (4), p.442-450</ispartof><rights>2005 INIST-CNRS</rights><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-45c149d53158d2c0c009b16240137239fc1cadf83d657cde1fb9cb13975399443</citedby><cites>FETCH-LOGICAL-c422t-45c149d53158d2c0c009b16240137239fc1cadf83d657cde1fb9cb13975399443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16720027$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15785925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WEICHERT, Wilko</creatorcontrib><creatorcontrib>KRISTIANSEN, Glen</creatorcontrib><creatorcontrib>WINZER, Klaus-Jürgen</creatorcontrib><creatorcontrib>SCHMIDT, Mathias</creatorcontrib><creatorcontrib>GEKELER, Volker</creatorcontrib><creatorcontrib>NOSKE, Aurelia</creatorcontrib><creatorcontrib>MÜLLER, Berit-Maria</creatorcontrib><creatorcontrib>NIESPOREK, Silvia</creatorcontrib><creatorcontrib>DIETEL, Manfred</creatorcontrib><creatorcontrib>DENKERT, Carsten</creatorcontrib><title>Polo-like kinase isoforms in breast cancer : expression patterns and prognostic implications</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><description>Polo-like kinase (PLK) family members are known to be functionally involved in mitotic signaling and in cytoskeletal reorganization in both normal and malignant cells. In this study, expression of PLK1 and PLK3 was determined immunohistochemically in tissue specimens of 135 breast carcinomas, and expression was correlated with clinicopathological parameters and patient prognosis. Strong PLK isoform overexpression was observed in 42.2% (PLK1) and 47.4% (PLK3) of breast carcinomas when compared with non-transformed breast tissue. A positive correlation of PLK isoform expression with tumor grade, vascular invasion, erbB2/HER-2 expression and markers of proliferative activity was evident. Additionally, an inverse correlation of PLK isoform expression and estrogen receptor status was observed. Overexpression of PLK3 but not of PLK1 was significantly linked to reduced median overall (P<0.001) and relapse-free (P=0.021) survival time. PLK3 expression remained an independent prognostic factor for overall (RR=3.2, P=0.002) and relapse-free (RR=2.9, P=0.049) survival in multivariate survival analysis. These results suggest PLK3 as a novel independent prognostic marker in breast cancer and hint toward a role for PLK isoform overexpression in disease progression. Therefore, in vivo inhibition of PLK family members might represent a rewarding approach in the development of new anticancer drugs for this tumor entity.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - enzymology</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - enzymology</subject><subject>Carcinoma, Ductal, Breast - mortality</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Lobular - enzymology</subject><subject>Carcinoma, Lobular - mortality</subject><subject>Carcinoma, Lobular - pathology</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Isoenzymes - metabolism</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Polo-Like Kinase 1</subject><subject>Prognosis</subject><subject>Protein Kinases - metabolism</subject><subject>Protein Serine-Threonine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Tumor Suppressor Proteins</subject><subject>Tumors</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkEuLFDEUhYMoTtv6A9xIEHSX8eZVSdzJ4GNgwFnoTgipVEoyU1Upc6th_Pem6YYBV3fz3XMOHyGvOVxyAPMBAZSwDEAzLrhg9gnZcSUFExLMU7IDpzTrJDcX5AXiHYDglnfPyQXXxmon9I78ui1TYVO-T_Q-LwETzVjGUmekeaF9TQE3GsMSU6UfaXpYa0LMZaFr2LZUF6RhGehay--l4JYjzfM65Ri2xuBL8mwME6ZX57snP798_nH1jd18_3p99emGRSXExpSOXLlBS67tICJEANfzTijg0gjpxshjGEYrh06bOCQ-9i72XDqjpXNKyT15f8ptO_4cEm5-zhjTNIUllQP6zhgrlO4a-PY_8K4c6tK2eSvACIBWuSf8BMVaEGsa_VrzHOpfz8EfvfuTd9-8-6N3b9vPm3PwoZ_T8PhxFt2Ad2cgYAzTWJvSjI9cdywXRv4Dqc2KKg</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>WEICHERT, Wilko</creator><creator>KRISTIANSEN, Glen</creator><creator>WINZER, Klaus-Jürgen</creator><creator>SCHMIDT, Mathias</creator><creator>GEKELER, Volker</creator><creator>NOSKE, Aurelia</creator><creator>MÜLLER, Berit-Maria</creator><creator>NIESPOREK, Silvia</creator><creator>DIETEL, Manfred</creator><creator>DENKERT, Carsten</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Polo-like kinase isoforms in breast cancer : expression patterns and prognostic implications</title><author>WEICHERT, Wilko ; KRISTIANSEN, Glen ; WINZER, Klaus-Jürgen ; SCHMIDT, Mathias ; GEKELER, Volker ; NOSKE, Aurelia ; MÜLLER, Berit-Maria ; NIESPOREK, Silvia ; DIETEL, Manfred ; DENKERT, Carsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-45c149d53158d2c0c009b16240137239fc1cadf83d657cde1fb9cb13975399443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - enzymology</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Ductal, Breast - enzymology</topic><topic>Carcinoma, Ductal, Breast - mortality</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Lobular - enzymology</topic><topic>Carcinoma, Lobular - mortality</topic><topic>Carcinoma, Lobular - pathology</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Estrogens</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Isoenzymes - metabolism</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Polo-Like Kinase 1</topic><topic>Prognosis</topic><topic>Protein Kinases - metabolism</topic><topic>Protein Serine-Threonine Kinases - metabolism</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><topic>Tumor Suppressor Proteins</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEICHERT, Wilko</creatorcontrib><creatorcontrib>KRISTIANSEN, Glen</creatorcontrib><creatorcontrib>WINZER, Klaus-Jürgen</creatorcontrib><creatorcontrib>SCHMIDT, Mathias</creatorcontrib><creatorcontrib>GEKELER, Volker</creatorcontrib><creatorcontrib>NOSKE, Aurelia</creatorcontrib><creatorcontrib>MÜLLER, Berit-Maria</creatorcontrib><creatorcontrib>NIESPOREK, Silvia</creatorcontrib><creatorcontrib>DIETEL, Manfred</creatorcontrib><creatorcontrib>DENKERT, Carsten</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WEICHERT, Wilko</au><au>KRISTIANSEN, Glen</au><au>WINZER, Klaus-Jürgen</au><au>SCHMIDT, Mathias</au><au>GEKELER, Volker</au><au>NOSKE, Aurelia</au><au>MÜLLER, Berit-Maria</au><au>NIESPOREK, Silvia</au><au>DIETEL, Manfred</au><au>DENKERT, Carsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polo-like kinase isoforms in breast cancer : expression patterns and prognostic implications</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><addtitle>Virchows Arch</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>446</volume><issue>4</issue><spage>442</spage><epage>450</epage><pages>442-450</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>Polo-like kinase (PLK) family members are known to be functionally involved in mitotic signaling and in cytoskeletal reorganization in both normal and malignant cells. In this study, expression of PLK1 and PLK3 was determined immunohistochemically in tissue specimens of 135 breast carcinomas, and expression was correlated with clinicopathological parameters and patient prognosis. Strong PLK isoform overexpression was observed in 42.2% (PLK1) and 47.4% (PLK3) of breast carcinomas when compared with non-transformed breast tissue. A positive correlation of PLK isoform expression with tumor grade, vascular invasion, erbB2/HER-2 expression and markers of proliferative activity was evident. Additionally, an inverse correlation of PLK isoform expression and estrogen receptor status was observed. Overexpression of PLK3 but not of PLK1 was significantly linked to reduced median overall (P<0.001) and relapse-free (P=0.021) survival time. PLK3 expression remained an independent prognostic factor for overall (RR=3.2, P=0.002) and relapse-free (RR=2.9, P=0.049) survival in multivariate survival analysis. These results suggest PLK3 as a novel independent prognostic marker in breast cancer and hint toward a role for PLK isoform overexpression in disease progression. Therefore, in vivo inhibition of PLK family members might represent a rewarding approach in the development of new anticancer drugs for this tumor entity.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15785925</pmid><doi>10.1007/s00428-005-1212-8</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma, Ductal, Breast - enzymology Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Carcinoma, Lobular - enzymology Carcinoma, Lobular - mortality Carcinoma, Lobular - pathology Cell Cycle Proteins - metabolism Estrogens Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Isoenzymes - metabolism Mammary gland diseases Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polo-Like Kinase 1 Prognosis Protein Kinases - metabolism Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Survival Analysis Survival Rate Tumor Suppressor Proteins Tumors |
| title | Polo-like kinase isoforms in breast cancer : expression patterns and prognostic implications |
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