Cytochrome P450 biosensors: a review
Cytochrome P450 (CYP) is a large family of enzymes containing heme as the active site. Since their discovery and the elucidation of their structure, they have attracted the interest of scientist for many years, particularly due to their catalytic abilities. Since the late 1970s attempts have concent...
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Veröffentlicht in: | Biosensors & bioelectronics 2005-06, Vol.20 (12), p.2408-2423 |
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creator | BISTOLAS, Nikitas WOLLENBERGER, Ulla JUNG, Christiane SCHELLER, Frieder W |
description | Cytochrome P450 (CYP) is a large family of enzymes containing heme as the active site. Since their discovery and the elucidation of their structure, they have attracted the interest of scientist for many years, particularly due to their catalytic abilities. Since the late 1970s attempts have concentrated on the construction and development of electrochemical sensors. Although sensors based on mediated electron transfer have also been constructed, the direct electron transfer approach has attracted most of the interest. This has enabled the investigation of the electrochemical properties of the various isoforms of CYP. Furthermore, CYP utilized to construct biosensors for the determination of substrates important in environmental monitoring, pharmaceutical industry and clinical practice. |
doi_str_mv | 10.1016/j.bios.2004.11.023 |
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subjects | Biological and medical sciences Biosensing Techniques - instrumentation Biosensing Techniques - methods Biosensors Biotechnology Coated Materials, Biocompatible - chemistry Cytochrome P-450 Enzyme System - analysis Cytochrome P-450 Enzyme System - chemistry Electrochemistry - instrumentation Electrochemistry - methods Electrodes Equipment Design Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Surface Plasmon Resonance - instrumentation Surface Plasmon Resonance - methods Various methods and equipments |
title | Cytochrome P450 biosensors: a review |
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