GATA-3 Expression as a Predictor of Hormone Response in Breast Cancer

Expression of estrogen receptor-α (ERα) as determined by immunohistochemistry of tumor tissue is currently the most clinically useful test to predict hormone responsiveness of breast cancer. Thirty percent of ERα-positive breast cancers do not respond to hormonal therapy. GATA-3 is a transcription f...

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Veröffentlicht in:	Journal of the American College of Surgeons 2005-05, Vol.200 (5), p.705-710
Hauptverfasser:	Parikh, Purvi, Palazzo, Juan P., Rose, Lewis J., Daskalakis, Constantine, Weigel, Ronald J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Case-Control Studies Female GATA3 Transcription Factor General aspects Humans Immunohistochemistry Logistic Models Medical sciences Middle Aged Pilot Projects Predictive Value of Tests Staining and Labeling Transcription Factors - metabolism
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